Psoriasis Associated With Tumor Necrosis Factor Inhibitors in Children With Inflammatory Diseases.

Arthritis Care & Research
Lisa H BuckleyPamela F Weiss

Abstract

To estimate the incidence rate (IR) of psoriasis in children with inflammatory bowel disease (IBD), juvenile idiopathic arthritis (JIA), and chronic noninfectious osteomyelitis (CNO) with tumor necrosis factor inhibitor (TNFi) exposure as compared to children without TNFi exposure and to the general pediatric population. This was a single-center retrospective cohort study of children with IBD, JIA, or CNO from 2008 to 2018. TNFi exposure was defined as a prescription for adalimumab, etanercept, infliximab, certolizumab, or golimumab, and the primary outcome was incident psoriasis. IRs and standardized incidence ratios (SIRs) were calculated. Cox proportional hazards models were used to assess the association of psoriasis with TNFi exposure and other risk factors. Of the 4,111 children who met inclusion criteria, 1,614 (39%) had TNFi exposure and 2,497 (61%) did not, with 4,705 and 6,604 person-years of follow-up, respectively. There were 58 cases (IR 12.3 per 1,000 person-years) and 25 cases (IR 3.8 per 1,000 person-years) of psoriasis in children with and without TNFi exposure, respectively. The SIR was 18 (95% confidence interval [95% CI] 15-22) overall, 30 (95% CI 23-39) for children with TNFi exposure, and 9.3 (95% CI 6.3-1...Continue Reading

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Citations

Oct 20, 2020·The Journal of Dermatological Treatment·Claudio ConfortiNicoleta Neagu
Aug 18, 2021·Pediatric Dermatology·Benoit M CyrenneCathryn Sibbald
Jan 29, 2022·Annals of the Rheumatic Diseases·Yongdong ZhaoTimothy Beukelman

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