Psoriasis: Association of interleukin-17 gene polymorphisms with severity and response to treatment

Experimental and Therapeutic Medicine
Alexandra Dana PușcașRemus Ioan Orăsan

Abstract

Psoriasis is a chronic, inflammatory disease with a complex pathogenesis that is not yet fully understood. Although it is a multifactorial disease, the genetic factor has a major role in the pathogenesis of psoriasis. Genome wide association studies have identified over 50 genetic loci associated with psoriasis risk. Beside TNF-α or IL-23, the IL-17 family is a newer group that has proven implications in the pathogenesis of psoriasis. The most important members of the family, with pro-inflammatory qualities, are IL-17A and IL-17F. These interleukins are produced by a varied number of cells, but by far the most important are Th17 cells. Of the patients 20-30% present moderate-to-severe psoriasis, therefore, systemic medication (phototherapy, methotrexate, cyclosporine, acitretin or biologic agents) is mandatory. The necessity of an individualized treatment plan, for each patient, is imperative in order to establish the best strategy for non-responders to classical treatment or to other biologic treatments. The discovery of Th17 pathway improved the treatment and prognosis of psoriasis. Anti-psoriatic agents against IL-17 or its receptors are a novel group of biologic agents; these include ixekizumab, secukinumab and brodalumab. ...Continue Reading

References

Oct 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·T StarnesR Hromas
Dec 4, 2004·The Journal of Allergy and Clinical Immunology·Mio KawaguchiShau-Ku Huang
Apr 28, 2006·American Journal of Human Genetics·Rajan P NairJames T Elder
Oct 10, 2006·Vitamins and Hormones·Sarah L GaffenFang Shen
Aug 7, 2007·Nature Immunology·Nicholas J WilsonRene de Waal Malefyt
Jul 11, 2008·Immunological Reviews·Laura A TesmerDavid A Fox
Jul 16, 2008·The Journal of Dermatological Treatment·Adam AsarchAlice B Gottlieb
Aug 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jill F WrightBeatriz M Carreno
Nov 20, 2008·The British Journal of Dermatology·C JohansenK Kragballe
Jan 10, 2009·Annual Review of Immunology·Thomas KornVijay K Kuchroo
Mar 20, 2009·The Journal of Investigative Dermatology·Erin G HarperAndrew Blauvelt
Jul 4, 2009·Nature Reviews. Immunology·Sarah L Gaffen
Jul 31, 2009·The New England Journal of Medicine·Frank O NestleJonathan Barker
Aug 28, 2009·The New England Journal of Medicine·Pierre MiossecVijay K Kuchroo
Dec 25, 2009·The Journal of Investigative Dermatology·Shinji KagamiAndrew Blauvelt
Feb 12, 2010·Archives of Dermatological Research·Sawa FujishimaMasafumi Iijima
Jun 29, 2010·Arthritis and Rheumatism·Jan LeipeAlla Skapenko
Oct 19, 2010·Nature Genetics·UNKNOWN Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium 2Richard C Trembath
Nov 19, 2010·The Journal of Investigative Dermatology·Andrea ChiricozziJames G Krueger
Dec 24, 2010·PloS One·Katrin PukelsheimMatthias Wjst
Apr 16, 2011·The Journal of Investigative Dermatology·Eliecer CotoVictoria Alvarez
Aug 20, 2011·Current Opinion in Immunology·Sarah L Gaffen
Oct 14, 2011·Nature Immunology·Vladimir Ramirez-CarrozziRajita Pappu
Jun 8, 2012·The Journal of Investigative Dermatology·David A MartinChris B Russell
Jun 22, 2012·The British Journal of Dermatology·G GirolomoniC Paul
Oct 2, 2012·Nature Reviews. Drug Discovery·Pierre Miossec, Jay K Kolls
Dec 21, 2012·Annals of the Rheumatic Diseases·Dhavalkumar D PatelChristian Antoni
Sep 27, 2013·Autoimmune Diseases·Rocío Prieto-PérezFrancisco Abad-Santos
Feb 21, 2014·The Journal of Dermatological Treatment·Mona MalakoutiEthan C Levin
Jun 7, 2014·Mediators of Inflammation·Constantin CăruntuEugen Mandache
Jul 19, 2014·Biomarkers in Medicine·Constantin CaruntuMonica Neagu
Sep 24, 2014·Clinical, Cosmetic and Investigational Dermatology·Ann Sophie LønnbergLone Skov
Nov 16, 2014·Actas dermo-sifiliográficas·A Chiricozzi
Jul 29, 2015·Journal of Autoimmunity·Jamie L HardenAnne M Bowcock
Oct 28, 2016·The Journal of Dermatology·Rika NishikawaChikako Nishigori
Jun 15, 2016·The New England Journal of Medicine·Kenneth B GordonUNKNOWN UNCOVER-3 Study Group
Sep 7, 2016·Dermatology : International Journal for Clinical and Investigative Dermatology·Monika BiałeckaMarek Droździk
Sep 28, 2016·The Pharmacogenomics Journal·A BatallaP Coto-Segura

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Oct 28, 2021·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Fridha Viridiana Villalpando-VargasOmar Graciano-Machuca

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