PMID: 8953411Nov 1, 1996Paper

Psoriasis: comparison of immunological markers in patients with acute and remission phase

Journal of Dermatological Science
O De PitàG De Sanctis

Abstract

The immune system involvement in psoriasis has been documented by the presence of activated T-cells both in peripheral blood and in psoriatic skin lesions and by the intervention of cytokines in the inflammatory process. On this basis, we have undertaken a study in order to examine, in addition to activation markers such as CD25 and CD54 (ICAM-1) on peripheral blood mononuclear cells (PBMNCs) surface, serum levels of soluble interleukin (IL)-2 receptor (sIL-2R), soluble ICAM-1 (sICAM-1), soluble CD4 (sCD4), soluble CD8 (sCD8), beta 2-microglobulin and fibronectin (FN) in psoriatic patients analyzed both in acute and remission phase obtained by topical therapy alone. Our results show that PBMNCs expressing IL-2 receptor (CD25) were increased both in percentage and absolute number in respect to controls, and were not modified after remission. On the contrary, the significantly higher number of CD54+ lymphocytes evaluated in acute psoriasis, showed a reduction during the remission phase, even if the values persisted higher than controls. Serum levels of sIL-2R, sICAM-1, sCD4, sCD8 and beta 2-microglobulin were significantly higher than controls both in acute and remission phase; only FN levels were found to be lower, in patients e...Continue Reading

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Citations

Oct 6, 2006·Archives of Dermatological Research·Ulrich MrowietzJonathan Barker
May 24, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Birgül Vanizor KuralAhmet Alver
Dec 20, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Marcia L E MacDonaldMichael R Hayden
Nov 13, 2001·Clinical and Experimental Immunology·H SigmundsdóttirH Valdimarsson
Dec 25, 2007·Archives of Dermatological Research·A M G LangewoutersP C M van de Kerkhof
May 25, 2002·The Journal of Dermatology·Habib AbulDonald Haines
Jun 21, 2007·The British Journal of Dermatology·P C M van de Kerkhof
Apr 5, 2013·The British Journal of Dermatology·E A DowlatshahiT Nijsten
Sep 25, 2007·Proteomics·Jeroen KoolAlbert J R Heck
May 18, 2010·The Journal of Rheumatology·Anne-Marie TobinBrian Kirby
Nov 17, 2001·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·L MigdalisF Mantzara
May 14, 2017·Experimental Dermatology·Katja BieberMichael Kasperkiewicz

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