PMID: 2106838Mar 1, 1990Paper

Psoriasis induced at the injection site of recombinant interferon gamma. Results of immunohistologic investigations

Archives of Dermatology
G FierlbeckC Müller

Abstract

Recombinant human interferon gamma used for treatment of psoriatic arthritis was found to induce expression of HLA-DR, but not HLA-DP or HLA-DQ, on keratinocytes at the site of injection. Some patients showed an improvement of their joint symptoms, but the cutaneous manifestations remained unaffected. In 10 of 42 patients, punctiform psoriatic foci could be induced at the site of injection of interferon gamma. For this presentation, we selected a female patient with psoriatic arthropathy and type II diabetes mellitus in whom psoriasis was induced at the site of application of interferon gamma, but not after subcutaneous injection of insulin or placebo. We conclude that interferon gamma is an important lymphokine in the development of psoriasis.

Citations

Jan 1, 1992·Archives of Dermatological Research·N I KimC Hammerberg
Aug 8, 2007·Archives of Dermatological Research·Sunit P Jariwala
Feb 1, 1993·Immunology Today·R L WongK D Cooper
Dec 20, 1995·Toxicology·T Vial, J Descotes
Mar 30, 2005·Journal of Dermatological Science·Z ShenY-F Liu
Oct 6, 1997·Clinics in Dermatology·H Tagami
Jun 27, 1998·Clinics in Dermatology·N TsankovK Drenovska
May 8, 1999·The British Journal of Dermatology·L AckermannM Horsmanheimo
May 13, 1999·International Journal of Dermatology·C Bonifati, F Ameglio
Nov 1, 1992·The British Journal of Dermatology·C C HarlandC A Holden
Aug 1, 1992·International Journal of Dermatology·B KumarE M Farber
May 1, 1994·International Journal of Dermatology·J Thivolet, J F Nicolas
May 1, 1994·International Journal of Dermatology·G S WoodR A Warnke
May 1, 1996·The Australasian Journal of Dermatology·H Rotstein
Apr 1, 1996·Experimental Dermatology·J SalogaJ Knop
Oct 15, 1996·The Journal of Clinical Investigation·T Wrone-Smith, B J Nickoloff
Nov 5, 1999·The Journal of Clinical Investigation·B J Nickoloff
Mar 5, 2014·Pathologie-biologie·M AmmarR Marrakchi
Jan 1, 1994·Archives of Dermatological Research·O J de BoerP K Das
Sep 26, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Roberto RomeroTinnakorn Chaiworapongsa
Sep 14, 2007·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Wojciech BaranEugeniusz Baran
Jan 27, 2012·The Journal of Investigative Dermatology·Leanne M Johnson-HuangMichelle A Lowes
Nov 22, 2005·The Journal of Investigative Dermatology·Karsten Wessel EriksenNiels Ødum
Mar 12, 2010·The Journal of Investigative Dermatology·Johann E GudjonssonJames T Elder
Jul 29, 2011·The Journal of Investigative Dermatology·Xiaowei ShiGang Wang
Mar 15, 2013·The Journal of Investigative Dermatology·Paola Di Meglio, João H Duarte
Apr 13, 2007·The Journal of Investigative Dermatology·Johann E GudjonssonJames T Elder
Aug 30, 2008·Clinics in Dermatology·Lars Alexander SchneiderKarin Scharffetter-Kochanek
Dec 1, 1990·Journal of the American Academy of Dermatology·K D CooperO Baadsgaard
Nov 21, 2007·Clinics in Dermatology·Kamran GhoreschiMartin Röcken
Nov 21, 2007·Clinics in Dermatology·Cristina AlbanesiGiampiero Girolomoni
Jan 15, 2015·Cytokine·Jaymie BaliwagAndrew Johnston
Jul 24, 2004·The British Journal of Dermatology·T KormeiliP S Yamauchi
Mar 25, 2005·The British Journal of Dermatology·V Quekenborn-TrinquetC E M Griffiths

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