Psoriasis Severity-A Risk Factor of Insulin Resistance Independent of Metabolic Syndrome

International Journal of Environmental Research and Public Health
Melita Vuksic PolicInes Bilic Curcic

Abstract

It is still debatable whether psoriasis increases cardiovascular risk indirectly since it is associated with metabolic syndrome or is an independent cardiovascular risk factor. The aim of this study was to evaluate psoriasis severity as an independent predictor of insulin resistance (IR) irrespective of the presence of metabolic syndrome (MetS). This was a case control study including 128 patients stratified into two groups: patients with psoriasis and metabolic syndrome vs. patients with psoriasis and no metabolic syndrome. MetS was diagnosed according to ATP III criteria with homeostatic model assessment of insulin resistance (HOMA-IR), as well as a homeostatic model assessment of beta cell function (HOMA-β) were calculated. Compared to subjects without metabolic syndrome, patients with metabolic syndrome had a significantly higher Psoriasis Area Severity Index (PASI) values (p < 0.001). The strongest correlation was established for HOMA-IR and the PASI index (p < 0.001), even after adjustment for body mass index (BMI) in regression analysis model. In patients without MetS and severe forms of disease, the HOMA-IR and HOMA-β values were significantly higher compared to mild forms of disease (p < 0.001 for all) while in subject...Continue Reading

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Citations

Jul 6, 2019·Mediators of Inflammation·Carmen Rodríguez-CerdeiraJosé Luís González-Cespón
Sep 25, 2020·Minerva endocrinologica·Claudio MarascaGiuseppina Fontanella
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Feb 16, 2021·American Journal of Clinical Dermatology·Sukhmani Pannu, David Rosmarin
Mar 30, 2021·International Journal of General Medicine·Amy W RachfalStanley S Schwartz

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