Psoriatic arthritis: tissue-directed inflammation?

Clinical Rheumatology
Giacomo Cafaro, Iain B McInnes

Abstract

The clinical picture of psoriatic arthritis (PsA) is heterogeneous, potentially involving numerous organs and tissues, such as skin and joint. From a clinical point of view, discrete tissue PsA features develop and respond to treatments apparently independently. The pathogenic events occurring in the various tissues are only partially understood. Although the vast majority of known genetic predisposing factors are shared between patients with skin psoriasis (PSO) and those affected by PsA, some tissue-specific variants have been identified. Furthermore, current data suggest that the TNF pathway and IL-23/Th17 pathways may be differentially activated in distinct tissue sites. In this review, we briefly describe current knowledge on the pathogenesis of PsA in terms of genetic predisposition, environmental factors and immunology, advancing our hypothesis to explain why a common immunologic process can express itself with significant differences in various tissues.

References

Sep 1, 1999·The Journal of Investigative Dermatology·N BalendranR C Trembath
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·P J CostelloO M FitzGerald
Oct 26, 2007·Journal of the European Academy of Dermatology and Venereology : JEADV·A M GrjibovskiJ R Harris
Nov 21, 2007·Clinics in Dermatology·Cristina AlbanesiGiampiero Girolomoni
Nov 28, 2007·The Journal of Experimental Medicine·Lisa C ZabaJames G Krueger
Jul 18, 2008·The Journal of Investigative Dermatology·Lisa C ZabaMichelle A Lowes
Jul 22, 2008·Nature Reviews. Immunology·Michel GillietYong-Jun Liu
Apr 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Leslie van der FitsErik Lubberts
May 9, 2009·Current Opinion in Rheumatology·Dennis McGonagleAi Lyn Tan
Aug 1, 2009·Trends in Immunology·Lars VereeckeGeert van Loo
Sep 8, 2009·Advances in Experimental Medicine and Biology·Michael Benjamin, Dennis McGonagle
Sep 21, 2010·Journal of the European Academy of Dermatology and Venereology : JEADV·C E M Griffiths
Oct 19, 2011·Arthritis and Rheumatism·Robert WinchesterOliver FitzGerald
Nov 8, 2011·Annual Review of Pathology·Gayathri K PereraFrank O Nestle
Feb 14, 2012·Arthritis and Rheumatism·Merja RuutuRanjeny Thomas
May 1, 2012·Cytokine & Growth Factor Reviews·Vincent P RamirezBrian J Aneskievich
Aug 2, 2012·Ultrastructural Pathology·Li Yun ZhangH Ralph Schumacher
Nov 3, 2012·Arthritis Research & Therapy·Matthew S DoyleStephen R Pennington
Apr 12, 2013·The British Journal of Dermatology·A S LønnbergS F Thomsen
Apr 29, 2014·Clinics in Dermatology·Ivan GrozdevNikolai Tsankov
Jul 10, 2014·The New England Journal of Medicine·Richard G LangleyUNKNOWN FIXTURE Study Group
Aug 20, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ia KhmaladzeRikard Holmdahl
Sep 23, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·C PaulUNKNOWN JUNCTURE study group
Nov 5, 2014·The Journal of Rheumatology·Maria Laura Acosta FelquerPhilip J Mease
Dec 10, 2014·Best Practice & Research. Clinical Rheumatology·Darren D O'Rielly, Proton Rahman
Dec 17, 2014·Arthritis & Rheumatology·Jennifer BelascoJames G Krueger
Mar 21, 2015·The Journal of Allergy and Clinical Immunology·Shunya MashikoMarika Sarfati
May 8, 2015·Arthritis Research & Therapy·Oliver FitzGeraldRobert Winchester
May 24, 2015·Current Opinion in Rheumatology·Tejpal GillRobert A Colbert
May 31, 2015·Lancet·Wolf-Henning Boehncke, Michael P Schön
Jul 4, 2015·Arthritis & Rheumatology·Emmerik F A LeijtenTimothy R D J Radstake
Sep 4, 2015·Arthritis & Rheumatology·Jose U ScherSteven B Abramson
Sep 18, 2015·Journal of Immunology Research·Ali Tahsin GunesLale Babayeva
Oct 18, 2015·Rheumatic Diseases Clinics of North America·Alexis Ogdie, Pamela Weiss

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Citations

May 28, 2019·Clinical Rheumatology·Jose A Leon de la RochaLuis R Espinoza
Sep 1, 2018·RMD Open·Joseph F MerolaRoy Fleischmann
Mar 7, 2020·International Journal of Immunopathology and Pharmacology·L A Bautista-HerreraJ F Muñoz-Valle
Sep 6, 2019·Nature Reviews. Rheumatology·Arlene Bravo, Arthur Kavanaugh
Oct 4, 2018·Frontiers in Immunology·Loredana FrascaRoberto Lande
Jul 13, 2021·Frontiers in Immunology·Aisling O'BrienDouglas J Veale

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