Psoriatic Synovitis: Singularity and Potential Clinical Implications

Frontiers in Medicine
Raquel CelisJuan D Caňete

Abstract

Psoriatic arthritis (PsA) is an immuno-inflammatory disease with a heterogeneous clinical presentation as affects musculoskeletal tissues (arthritis, enthesitis, spondylitis), skin (psoriasis) and, less frequently, eye (uveitis) and bowel (inflammatory bowel disease). It has been suggested that distinct affected tissues could exhibit different immune-inflammatory pathways so complicating the understanding of the physiopathology of psoriatic disease as well as its treatment. Despite of the key pathogenic and clinical relevance that enthesitis has in PsA, peripheral arthritis is more easily perceived. At the macroscopic level, PsA synovitis has predominantly tortuous, bushy vessels, whereas rheumatoid arthritis (RA) is characterized by mainly straight, branching vessels so reflecting prominent neo-angiogenesis in PsA. Synovial biopsies have demonstrated a similar cellular and molecular picture in PsA and RA, although some differences have been reported at the group level, as higher density of vessels, CD163+ macrophages, neutrophils and mast cells in PsA. In fact, synovial IL-17+ mast cells are significantly increased in PsA and produce more IL-17A compared with RA, and a proof of concept study supports its relevant role in the s...Continue Reading

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Citations

Mar 10, 2020·Expert Review of Clinical Immunology·Francesco CasoLuisa Costa
Aug 12, 2020·The Journal of International Medical Research·Qianjun JinHui Lu
Apr 4, 2021·International Journal of Molecular Sciences·Dan-In JangSeung-Hoon Yang
May 11, 2021·Frontiers in Medicine·Fernando Saraiva
Jul 30, 2021·International Journal of Rheumatic Diseases·Robert W Ike, Kenneth C Kalunian

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Methods Mentioned

BETA
biopsies
confocal microscopy
biopsy
PCR

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