pSTAT3+ Reactive Astrocytes Promote Brain Metastasis

Trends in Molecular Medicine
Minhong Shen, Yibin Kang

Abstract

The tumor microenvironment contains heterogeneous populations of stromal cells with important roles in cancer progression and metastasis. In a recent study published in Nature Medicine, pSTAT3+ reactive astrocytes were found to promote brain metastasis by altering the tumor microenvironment, and represent a promising target for the treatment of brain metastasis.

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