Psychedelics: Where we are now, why we got here, what we must do

Neuropharmacology
Sean J Belouin, Jack E Henningfield

Abstract

The purpose of this commentary is to provide an introduction to this special issue of Neuropharmacology with a historical perspective of psychedelic drug research, their use in psychiatric disorders, research-restricting regulatory controls, and their recent emergence as potential breakthrough therapies for several brain-related disorders. It begins with the discovery of lysergic acid diethylamide (LSD) and its promising development as a treatment for several types of mental illnesses during the 1940s. This was followed by its abuse and stigmatization in the 1960s that ultimately led to the placement of LSD and other psychedelic drugs into the most restrictively regulated drug schedule of the United States Controlled Substances Act (Schedule I) in 1970 and its international counterparts. These regulatory controls severely constrained development of psychedelic substances and their potential for clinical research in psychiatric disorders. Despite the limitations, there was continued research into brain mechanisms of action for psychedelic drugs with potential clinical applications which began during the 1990s and early 2000s. Finding pathways to accelerate clinical research in psychedelic drug development is supported by the gro...Continue Reading

Citations

Mar 7, 2019·Journal of Psychoactive Drugs·Jacob S AdayChristopher C Davoli
Apr 19, 2019·Advances in Physiology Education·Martina A ClarkeAlicia M Schiller
May 8, 2019·Anaesthesia·S M White
Jul 16, 2019·Journal of Psychopharmacology·Kim Pc KuypersDavid Nutt
Apr 1, 2020·Journal of Music Therapy·Clare O'CallaghanMargaret Ross
Sep 11, 2020·International Journal of Molecular Sciences·Matas Vitkauskas, Ajay S Mathuru
Aug 30, 2020·Academic Psychiatry : the Journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry·Alan K LouieAdam M Brenner
Nov 20, 2019·Theoretical Medicine and Bioethics·Daniel P Sulmasy
Nov 25, 2020·Molecular Biology Reports·Alec J DiVito, Robert F Leger
Jan 10, 2021·Psychopharmacology·C J Healy
Jun 5, 2020·Medical Hypotheses·E S Lansky
Jan 26, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Talise E MüllerDenis B Rosemberg
Feb 12, 2020·Journal of the Neurological Sciences·Tingying Chi, Jessica A Gold
Jul 31, 2021·Frontiers in Psychology·Sascha B ThalPetra M Skeffington
Jul 14, 2021·Journal of Medical Ethics·Dana StraussMonnica T Williams
Oct 29, 2019·ACS Chemical Neuroscience·Christian B M PoulieJesper L Kristensen
Sep 17, 2021·Advances in Physiology Education·Elijah M K Haynes, Jennifer M Jakobi

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