Psychiatric behaviors associated with cytoskeletal defects in radial neuronal migration

Cellular and Molecular Life Sciences : CMLS
Toshifumi Fukuda, Shigeru Yanagi

Abstract

Normal development of the cerebral cortex is an important process for higher brain functions, such as language, and cognitive and social functions. Psychiatric disorders, such as schizophrenia and autism, are thought to develop owing to various dysfunctions occurring during the development of the cerebral cortex. Radial neuronal migration in the embryonic cerebral cortex is a complex process, which is achieved by strict control of cytoskeletal dynamics, and impairments in this process are suggested to cause various psychiatric disorders. Our recent findings indicate that radial neuronal migration as well as psychiatric behaviors is rescued by controlling microtubule stability during the embryonic stage. In this review, we outline the relationship between psychiatric disorders, such as schizophrenia and autism, and radial neuronal migration in the cerebral cortex by focusing on the cytoskeleton and centrosomes. New treatment strategies for psychiatric disorders will be discussed.

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Citations

Sep 28, 2017·Molecular Psychiatry·A ChefferH Ulrich
Jul 10, 2018·Cerebral Cortex·Chen LiangBonnie L Firestein
Mar 20, 2019·Frontiers in Psychiatry·Michal Pruski, Bing Lang
Oct 18, 2019·Frontiers in Cell and Developmental Biology·Yi-Hsuan PanXiao-Bing Yuan
May 28, 2020·Frontiers in Psychiatry·Guglielmo LuccheseBenjamin Stahl
Oct 13, 2020·Frontiers in Cell and Developmental Biology·Claudia Peregrina, Daniel Del Toro
Apr 2, 2021·Scientific Reports·Mariko UmemuraYuji Takahashi
Jul 24, 2021·The Journal of Biological Chemistry·Shohei OkudaToshifumi Fukuda

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Methods Mentioned

BETA
nuclear translocation
acetylation
GTPase

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