Abstract
Psychiatric comorbidities play a key role in patient selection for left ventricular assist devices (LVADs), but their impact on clinical outcomes is unknown. The goal of this study was to examine the clinical impact of psychiatric illness on outcomes in patients receiving LVADs for end-stage heart failure (HF). The study identified adults in the Interagency Registry for Mechanically Assisted Circulatory Support with psychiatric comorbidities (history of alcohol abuse, drug use, narcotic dependence, depression, and other major psychiatric diagnoses) receiving continuous-flow LVADs from 2008 to 2017. Demographic characteristics, survival, adverse events, and quality of life scores were compared for patients with and without each psychiatric comorbidity. Over the study period, the prevalence of psychiatric comorbidities was low: alcohol abuse, n = 1,093 (5.5%); drug use, n = 1,077 (5.4%); narcotic dependence, n = 96 (0.5%); depression, n = 401 (2.0%); and other major psychiatric illnesses, n = 265 (1.4%). Narcotic dependence (adjusted hazard ratio: 1.9; 95% confidence interval: 1.2 to 3.0; p = 0.004) and other major psychiatric illnesses (adjusted hazard ratio: 1.4; 95% confidence interval: 1.0 to 1.9; p = 0.02) were associated wi...Continue Reading
References
Oct 18, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·James K KirklinJames B Young
Oct 18, 2011·The Annals of Thoracic Surgery·John D PuskasMichael Halkos
Jun 13, 2012·Circulation·Tariq AhmadJoseph G Rogers
Jan 15, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·James K KirklinMarissa A Miller
Apr 12, 2014·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Jesse C Stewart, Bruce L Rollman
Aug 12, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Rebecca CogswellPeter Eckman
Feb 3, 2015·Psychiatric Services : a Journal of the American Psychiatric Association·Brian K AhmedaniGregory E Simon
Mar 31, 2015·Drug and Alcohol Dependence·Jermaine D Jones, Sandra D Comer
Jun 4, 2015·JAMA Psychiatry·Bridget F GrantDeborah S Hasin
Nov 7, 2015·American Heart Journal·David SnipeliskyShannon M Dunlay
Nov 19, 2015·JAMA Psychiatry·Bridget F GrantDeborah S Hasin
Jun 16, 2016·Circulation. Heart Failure·Kristin E BergethonAdrian F Hernandez
Apr 13, 2017·The New England Journal of Medicine·Sean A CoadyCarol A Giffen
Sep 26, 2017·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·James K KirklinDavid C Naftel
Oct 14, 2017·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Jesus M CasidaJames J Yang
Nov 19, 2017·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jason O RobertsonScott C Silvestry
Dec 7, 2017·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Scott LundgrenCecilia Poon
Feb 17, 2018·JAMA Psychiatry·Deborah S HasinBridget F Grant
Jan 30, 2019·The Annals of Thoracic Surgery·Robert L KormosJames K Kirklin
Jul 28, 2019·Scientific Reports·Crispino TostoGregory Ewald
Citations
Nov 25, 2020·Journal of Cardiothoracic and Vascular Anesthesia·Archer Kilbourne MartinHarish Ramakrishna
Jun 6, 2021·American Heart Journal·Jonathan J EdwardsEdo Y Birati
Aug 16, 2021·Journal of the Academy of Consultation-Liaison Psychiatry·Joy ChoiMark Nickels