Psychiatric disorders and cognitive dysfunction among older, postmenopausal women: results from the Women's Health Initiative Memory Study.

The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
Christopher C ColendaGloria E Sarto

Abstract

To estimate the frequency of depressive symptoms and selected psychiatric disorders in the Women's Health Initiative Memory Study (WHIMS) cohort and related them to cognitive syndromes. WHIMS was a randomized, double-blinded, placebo-controlled prevention clinical trial examining whether opposed and unopposed hormone therapy reduced the risk of dementia in healthy postmenopausal women. Participants scoring below a designated cutpoint on a cognitive screener received a comprehensive neuropsychiatric workup and adjudicated outcome of no cognitive impairment, mild cognitive impairment, or probable dementia. Seven thousand four hundred seventy-nine WHIMS participants between age 65 and 79 years and free of dementia at the time of enrollment in WHIMS. Five hundred twenty-one unique participants contributed complete data required for these analyses. Depressive symptoms were measured with the 15-item Geriatric Depression Scale and the presence of selected psychiatric disorders (major depression, generalized anxiety, and panic and alcohol abuse) was made using the PRIME-MD. The 18% of women had at least one psychiatric disorder with depression being the most common (16%) followed by general anxiety or panic (6%) and alcohol abuse (1%)....Continue Reading

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Citations

Jun 12, 2013·Journal of Aging and Physical Activity·Casey Jordan MaceNgaire Kerse
Nov 20, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Z ButtA DiMartini
Jan 14, 2012·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Guo-Lin Chen, Gregory M Miller
May 2, 2020·Voprosy kurortologii, fizioterapii, i lechebnoĭ fizicheskoĭ kultury·T V Builova, L A Marchenkova
Feb 13, 2013·Acta Neurologica Scandinavica·Y UemuraK Nakashima
Nov 9, 2011·Depression and Anxiety·Thilo DeckersbachMichael W Otto

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