Psychiatric genetics: search for phenotypes

Trends in Neurosciences
M LeboyerJ Mallet

Abstract

Failure to obtain convincing results in psychiatric genetics can partly be attributed to the fact that progress in molecular biology and genetic epidemiology has not been followed by an equivalent development in phenotypic description. Instead of relying entirely on classical nosological approaches, we argue that identifying more homogeneous forms of diseases through a'candidate symptom approach' among affected subjects and an endophenotype approach that identifies sub-clinical traits among non-affected relatives might yield better results. Examples where these strategies have already been fruitful when applied to complex diseases are presented in this review. Focusing on vulnerability traits might stimulate the redefinition of traditional psychiatric syndromes and help to bridge the gap between clinical and experimental approaches.

References

Dec 1, 1992·Nature Genetics·P St George-HyslopD Crapper McLachlan
Oct 1, 1992·Journal of Psychiatric Research·S Matthysse, J Parnas
Feb 1, 1992·Psychiatry Research·M LeboyerD Widlöcher
Aug 9, 1991·Science·K W KinzlerD McKechnie
Jan 1, 1990·Schizophrenia Bulletin·M V Seeman, M Lang
Jan 1, 1990·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·J B CraccoP J Maccabee
Mar 1, 1990·Archives of Internal Medicine·R R WilliamsH Kuida
Oct 1, 1994·The British Journal of Psychiatry : the Journal of Mental Science·P C ShamR Murray
Sep 30, 1994·Science·E S Lander, N J Schork
Jan 1, 1994·Schizophrenia Bulletin·B A Cornblatt, J G Keilp
Jan 1, 1994·Schizophrenia Bulletin·D L LevyN R Mendell
Jan 1, 1994·Schizophrenia Bulletin·D Friedman, E Squires-Wheeler
Sep 1, 1993·The British Journal of Psychiatry : the Journal of Mental Science·M T Tsuang
Apr 1, 1996·Nature Genetics·N Risch, D Botstein

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Citations

Jul 5, 2005·European Archives of Psychiatry and Clinical Neuroscience·Wolfgang MaierMarcella Rietschel
Sep 16, 2006·European Archives of Psychiatry and Clinical Neuroscience·Christian Jacob, Klaus-Peter Lesch
Sep 1, 2005·Human Genetics·Patrick T EllinorCalum A MacRae
Dec 31, 2011·Human Genetics·Eric W KleeStephen C Ekker
Jul 2, 2008·Journal of Autism and Developmental Disorders·Jeremy GoldbergPeter Szatmari
Sep 18, 2001·Current Psychiatry Reports·J M RyanP N Tariot
Nov 19, 2003·European Journal of Pharmacology·David A Collier, Tao Li
Jun 9, 2004·Journal of Affective Disorders·Vincent CamusGérard Waeber
Feb 6, 2004·Journal of Psychiatric Research·Ulrich EttingerTonmoy Sharma
Mar 4, 2000·Journal of Psychiatric Research·C SobinM Karayiorgou
Dec 7, 2002·Psychiatry Research·Janusz K RybakowskiJoanna Hauser
Dec 19, 1998·Psychiatry Research·M LeboyerW Maier
Jun 5, 2002·Trends in Genetics : TIG·Charles E Glatt, Nelson B Freimer
Oct 19, 2002·Biological Psychology·Eco J C de Geus
Feb 6, 2002·Brain Research Bulletin·Yan ClémentCatherine Belzung
Mar 22, 2003·Schizophrenia Research·Franck SchürhoffMarion Leboyer
Oct 24, 2000·Schizophrenia Research·G K ThakerJ Sherr
Jun 22, 2001·European Psychiatry : the Journal of the Association of European Psychiatrists·Y ClémentG Chapouthier
Jan 28, 2003·European Psychiatry : the Journal of the Association of European Psychiatrists·Andrei SzökeMarion Leboyer
Mar 8, 2005·Drug Discovery Today·Travis DunckleyDietrich A Stephan
Jan 14, 2004·Psychological Bulletin·Kent E HutchisonAngela Bryan
Jan 11, 2007·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Angela BryanDavid L Allen
Feb 12, 2002·Nature Reviews. Genetics·Maja Bućan, Ted Abel
May 12, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Richard DelormeMarion Leboyer
Feb 24, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ghazal ZaboliRosario Leopardi
Mar 20, 2010·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Sara Jane WebbGeraldine Dawson
May 20, 2003·Neurotoxicity Research·Bárbara AriasLourdes Fañanás
Oct 20, 2006·Journal of Clinical and Experimental Neuropsychology·Ralf PukropJoachim Klosterkötter
Jul 23, 2005·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Lorraine CaronBarbara A Koenig
Sep 22, 2011·Brain : a Journal of Neurology·Maria StamelouKailash P Bhatia
Mar 18, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Helen Tager-Flusberg, Robert M Joseph
Mar 2, 2006·Genes, Brain, and Behavior·T D Gould, I I Gottesman
May 22, 2010·Interdisciplinary Perspectives on Infectious Diseases·Marco Bortolato, Sean C Godar
Dec 25, 2009·Circulation. Cardiovascular Genetics·Carolyn Y Ho, Calum A MacRae
Oct 8, 2004·Pharmacogenomics·C FlordellisA Lymperopoulos

❮ Previous
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