Psychiatric morbidity and suicidal behaviour in psoriasis: a primary care cohort study.

The British Journal of Dermatology
Rosa ParisiDarren M Ashcroft

Abstract

Psychological distress among people with psoriasis may lead to elevated risks of suicide and nonfatal self-harm. To investigate psychiatric comorbidity, psychotropic medication prescribing and risk of suicidality in people with psoriasis. A cohort of patients with psoriasis (1998-2014) was delineated using the Clinical Practice Research Datalink, with linkage to Hospital Episode Statistics and Office for National Statistics mortality records. Each patient with psoriasis was matched with up to 20 patients without psoriasis on age, sex and general practice. A stratified Cox regression model was used to estimate the hazard ratios (HRs) for suicide or nonfatal self-harm risks adjusted for socioeconomic status. At baseline, among 56 961 and 876 919 patients with and without psoriasis, higher prevalence for histories of alcohol misuse, bipolar disorder, depression, anxiety disorders, self-harm and psychotropic drug prescription were observed. The deprivation-adjusted HR indicated lower suicide risk in people with psoriasis [HR 0·59, 95% confidence interval (CI) 0·41-0·85]. The risk of suicide varied according to age: it was lower in people with psoriasis diagnosed at ≥ 40 years (HR 0·38, 95% CI 0·21-0·66), whereas there was no differ...Continue Reading

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Citations

Jan 7, 2020·The Journal of Dermatological Treatment·Peter C M van de Kerkhof, Steven R Feldman
Nov 30, 2019·American Journal of Clinical Dermatology·Shu-Hui WangTao-Hsin Tung
Nov 25, 2018·International Journal of Impotence Research·Shankun ZhaoZhigang Zhao
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Mar 27, 2021·Indian Dermatology Online Journal·Sandeep GroverAjit Avasthi

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