Psychiatric Phenotypes of Pediatric Patients With Seropositive Autoimmune Encephalitis.

Hospital Pediatrics
Ashley V AdamsGenaLynne C Mooneyham

Abstract

Patients with autoimmune encephalitis (AE) often present with symptoms that are broadly characterized as psychiatric or behavioral, yet little attention is given to the precise symptomatology observed. We sought to more fully define the psychiatric symptoms observed in patients with anti-N-methyl-D-aspartate receptor (NMDAR), anti-glutamic-acid-decarboxylase 65 (GAD65), and anti-voltage-gated-potassium-channel complex (VGKC) antibody-mediated AE using the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition nomenclature. We present a case series (n = 25) using a retrospective chart review of 225 patients evaluated for AE in a tertiary care academic medical center between 2014 and 2018. The included patients were ≤18 years old with anti-NMDAR AE (n = 13), anti-GAD65 AE (n = 7), or anti-VGKC AE (n = 5). The frequency of neuropsychiatric symptoms present at the onset of illness and time to diagnosis were compared across groups. Psychiatric symptoms were seen in 92% of patients in our cohort. Depressive features (72%), personality change (64%), psychosis (48%), and catatonia (32%) were the most common psychiatric symptoms exhibited. On average, patients experienced impairment in ≥4 of 7 symptom domains. No patients ...Continue Reading

References

May 4, 2010·Annals of Neurology·Michael P MalterChristian G Bien
Mar 23, 2011·Journal of Affective Disorders·Pascal SienaertJürgen De Fruyt
Nov 21, 2012·The Journal of Pediatrics·Thaís ArmangueUNKNOWN Spanish Anti-N-methyl-D-Aspartate Receptor (NMDAR) Encephalitis Work Group
Feb 26, 2016·Lancet Neurology·Francesc GrausJosep Dalmau
Apr 3, 2016·Neurology·Agnes van SonderenMaarten J Titulaer
Apr 27, 2016·Journal of Pediatric Endocrinology & Metabolism : JPEM·Ema GriloAlice Mirante
Jul 1, 2013·European Neurological Review·Frank LeypoldtJosep Dalmau
Feb 25, 2017·Current Opinion in Neurology·Russell C DaleMing Lim
Apr 19, 2017·Nature Reviews. Neurology·Agnes van SonderenMaarten J Titulaer
Jul 19, 2017·Hospital Pediatrics·Katherine A S GallagherPatricia Ibeziako
Nov 21, 2017·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Bahadir KonuskanBanu Anlar
Nov 22, 2017·Child and Adolescent Psychiatric Clinics of North America·GenaLynne C MooneyhamHeather Van Mater
Jan 27, 2018·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Nedia Ben AchourIlhem Ben Youssef-Turki
Aug 5, 2018·Annals of Neurology·A Sebastian López-ChiribogaSean J Pittock
May 28, 2019·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Magnus Spangsberg BoesenMalene Landbo Børresen
Jan 19, 2020·Neurology. Neuroimmunology and Neuroinflammation·Tania CellucciRussell C Dale
May 7, 2020·Epilepsy & Behavior : E&B·Raia A BlumAnusha K Yeshokumar

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