Psychiatric profile of motor subtypes of de novo drug-naïve Parkinson's disease patients

Brain and Behavior
Francesca AssognaA Stefani

Abstract

Parkinson's disease (PD) is a heterogeneous neurodegenerative disorder. It is well established that different motor subtypes of PD evolve with different clinical courses and prognoses. The complete psychiatric profile underlying these different phenotypes since the very early stage of the disease is debated. We aimed at investigating the psychiatric profile of the three motor subtypes of PD (akinetic-rigid, tremor-dominant, and mixed) in de novo drug-naïve patients with PD. Sixty-eight patients with PD, divided into 39 akinetic-rigid (AR), seven mixed (MIX), and 22 tremor-dominant (TD) patients underwent a complete assessment of psychiatric, cognitive, and motor symptoms. No significant differences were found among groups. Our results suggest that a differentiation of the psychiatric symptoms associated with specific motor subtypes of PD is not detectable in de novo drug-naïve patients. Previous evidence that emerges later along the disease progression may be a consequence of the dopaminergic and nondopaminergic damage increase.

References

Jan 1, 1994·Journal of Psychosomatic Research·R M BagbyJ D Parker
Jun 15, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Gail A KangBeate Ritz
Jan 13, 2009·Archives of Gerontology and Geriatrics·Joo Young OhAe Young Lee
Jun 6, 2009·Current Opinion in Neurology·Adam ZaidelHagai Bergman
May 7, 2011·Psychotherapy and Psychosomatics·Michele PolettiUbaldo Bonuccelli
Jun 11, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Magdalena Eriksson DomellöfLars Forsgren
Apr 12, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·Michele PolettiUbaldo Bonuccelli
Jan 9, 2014·Frontiers in Systems Neuroscience·Ahmed A Moustafa, Michele Poletti
Dec 2, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Francesco E PontieriGianfranco Spalletta
Dec 3, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Claustre Pont-SunyerEduardo Tolosa
Oct 16, 2015·Parkinsonism & Related Disorders·Anna SauerbierK Ray Chaudhuri

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Citations

Nov 20, 2019·Annals of Clinical and Translational Neurology·Suaad Abd ElhadiRonit Sharon
Jan 21, 2021·Journal of Personalized Medicine·Francesca AssognaClelia Pellicano

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