PMID: 9175196Jun 1, 1997Paper

Psychiatrists' responses to failure of maintenance therapy with antidepressants

Psychiatric Services : a Journal of the American Psychiatric Association
S Byrne, A J Rothschild

Abstract

Some patients being treated for recurrent major depression experience a return of depressive symptoms despite a constant maintenance dose of an antidepressant, a phenomenon known as breakthrough depression. A total of 145 psychiatrists who were members of the Massachusetts Psychiatric Society responded to a survey about intervention in hypothetical cases of breakthrough depression if the patient was taking either 20 mg of fluoxetine, 100 mg of sertraline, 100 mg of nortriptyline, or 40 mg of fluoxetine. For all drugs and dosages, the most popular choice was increasing the dosage, followed by augmenting with lithium or another antidepressant or changing to a different drug.

Citations

Jul 9, 2011·Depression Research and Treatment·Luis M Martín-LópezJulio Vallejo
Jan 9, 2001·The Psychiatric Clinics of North America·A A Nierenberg, J E Alpert
Nov 26, 2005·Acta Psychiatrica Scandinavica. Supplementum·J E RojoJ M de Pedro
Oct 3, 2006·The British Journal of Psychiatry : the Journal of Mental Science·Henricus G RuhéAart H Schene
Jul 20, 2000·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·D MischoulonM Fava
Sep 29, 1999·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·C BeckJ Dunn
Nov 16, 2018·Journal of Affective Disorders·Gustavo KinrysMaurizio Fava

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