PMID: 9533390Apr 9, 1998Paper

Psychic trauma causing grossly reduced brain metabolism and cognitive deterioration

Neuropsychologia
H J MarkowitschW D Heiss

Abstract

While amnesia and other cognitive disturbances are usually caused by structural brain damage, there are a few instances in which environmental stress may induce neuronal death in memory-sensitive brain regions such as the hippocampus. Here we report on a patient who, after a single brief exposure to an event reminding him of a similar stressful event from his childhood, deteriorated immediately and persistently without manifesting structural, but manifesting functional, brain damage as measured by position emission tomography. This patient probably represents the first case in which a direct relation between a single psychic event and the occurrence of brain malfunctioning in cognition is documented by dynamic neuroimaging methods. Psychic shock may cause lasting reductions in brain metabolism with the consequence of severe intellectual malfunctioning.

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Citations

Dec 5, 2008·European Archives of Psychiatry and Clinical Neuroscience·Hans J Markowitsch
Nov 5, 2003·NeuroImage·Hans J Markowitsch
Apr 13, 2000·Behaviour Research and Therapy·A Ehlers, D M Clark
Nov 24, 2004·The Australian and New Zealand Journal of Psychiatry·Onno van der HartDaniel Brown
Dec 18, 2007·Psychiatry and Clinical Neurosciences·Sanjay KumarBangalore N Gangadhar
Jan 1, 2013·ISRN Neuroscience·Hans J Markowitsch
May 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jonathan KipnisMichal Schwartz
Sep 12, 2015·The Lancet. Psychiatry·Angelica Staniloiu, Hans J Markowitsch
Oct 5, 2014·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Elsa KaphanAndré Ali Chérif
Oct 19, 2010·Consciousness and Cognition·Hans J Markowitsch, Angelica Staniloiu
Dec 6, 2002·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Hans J Markowitsch
Apr 5, 2008·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Esther FujiwaraHans J Markowitsch
Mar 16, 2007·Brain Research·Sung-Eun KimSeon Wan Ki
Sep 1, 2015·Neuropsychology Review·Shailendra SegobinFrancis Eustache
Nov 20, 2003·Biological Psychiatry·Omer BonneArieh Y Shalev
Jul 27, 2010·Consciousness and Cognition·Angelica StaniloiuMatthias Brand
May 25, 2010·Neuropsychologia·Christine N SmithLarry R Squire
Jul 25, 2012·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Hans J Markowitsch, Angelica Staniloiu
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Jan 1, 2012·Brain Sciences·Angelica Staniloiu, Hans J Markowitsch
Mar 27, 2001·The International Journal of Neuroscience·J KesslerW D Heiss

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