Psychologic distress after disclosure of genetic test results regarding hereditary nonpolyposis colorectal carcinoma

Cancer
Yoshie MurakamiY Uchitomi

Abstract

To the authors' knowledge, there have been few studies of the psychologic distress after disclosure of genetic test results for hereditary nonpolyposis colorectal carcinoma (HNPCC). The objectives of this study were to identify the prevalence rates and predictors of psychologic distress and to evaluate the feelings of guilt after disclosure of the test results in Japanese probands and unaffected relatives. Probands and unaffected relatives were interviewed immediately after the first genetic counseling session for HNPCC and again 1 month after disclosure of the genetic test results. The prevalence of major and minor depression, acute stress disorder (ASD), posttraumatic stress disorder (PTSD), and posttraumatic stress symptoms (PTSS) were assessed using the Structured Clinical Interview based on the Diagnostic and Statistical Manual of Mental Disorders, 3rd edition revised (DSM-III-R) or the DSM-IV; feelings of guilt were investigated using a numeric scale and a semistructured interview. Among 47 participants who completed the baseline interview, 42 participants (89%) completed the 1-month follow-up interview. Although none of the participants met the criteria for major depression, ASD, or PTSD at the follow-up interview, 3 of ...Continue Reading

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Citations

Jan 27, 2011·Journal of Genetic Counseling·Helle Vendel PetersenMef Nilbert
Jan 17, 2008·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Jodi T HeshkaPhilip S Wells
May 15, 2013·Familial Cancer·Eveline M A BleikerAndrea Farkas Patenaude
Sep 23, 2014·Cancer·April Malia HirschbergWilliam F Pirl
May 15, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ravi N SharafUri Ladabaum
Mar 20, 2015·Digestive Diseases and Sciences·Polymnia GaliatsatosWilliam D Foulkes
Oct 2, 2019·Clinical Genetics·Jeanette YuenJoanne Ngeow
Sep 25, 2019·Cold Spring Harbor Perspectives in Medicine·Jaclyn Schienda, Jill Stopfer
Feb 27, 2015·Hormone Molecular Biology and Clinical Investigation·Hendrik UngefrorenHendrik Lehnert

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