Psychological and somatic subjective symptoms as a result of dermatological patch testing with metallic mercury and phenyl mercuric acetate

Toxicology Letters
J A Marcusson

Abstract

Sixty patients with a history of malaise over the ensuing weeks following the drilling out of old amalgam fillings were included in the study. They were tested epicutaneously weekly (standard procedure) with either 0.5% metallic mercury in petrolatum or 0.01% phenyl mercuric acetate in water, and, on 2 separate occasions, with only saline or petrolatum as a control according to a randomized double-blind protocol. The presence or absence of an allergic patch test response was read on day 3. Two patients showed allergic cutaneous responses towards metallic mercury and 1 to phenyl mercuric acetate. There was a concurrent 7-day self-registration of subjective psychological and somatic symptoms, using a validated visual analogue scale (minor symptom evaluation profile; MSE). In the group analysis it was clearly shown that the patients reacted with subjective symptoms to phenyl mercuric acetate. A reaction to test doses of metallic mercury seems to exist but could only be visualized when a scoring system was elaborated to individually define those subjects with a psychological and somatic response to test doses of mercury. This psychosomatic reactivity, named intolerance, seems to be unrelated to the cutaneous delayed allergic skin r...Continue Reading

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Citations

May 22, 1998·Journal of Dentistry·R StrangD Woods
May 4, 2000·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J A MarcussonL G Gunnarsson
Aug 1, 1998·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J A Marcusson, C Jarstrand
Jul 17, 1998·Contact Dermatitis·J A MarcussonJ Heilborn
May 27, 1999·Contact Dermatitis·J A MarcussonB Evengård
Jan 15, 2011·Journal of Occupational Medicine and Toxicology·Joachim Mutter
Jul 27, 2005·Toxicological Reviews·Amy M BrownawellMeryl H Karol
Jul 31, 2007·Critical Reviews in Toxicology·Joachim MutterCorina Guethlin
Mar 1, 1997·Critical Reviews in Toxicology·J C Rowlands, J A Gustafsson
Jan 24, 2009·European Child & Adolescent Psychiatry·Julia Kim-CohenTerrie E Moffitt
Apr 20, 2012·Critical Reviews in Toxicology·Shakil Ahmed SaghirAlene Theresa McCoy
Sep 6, 2000·The British Journal of Dermatology·L KunkelerD P Bruynzeel

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