Psychological Biomarkers and Fibrosis: An Innovative Approach to Non-alcoholic Fatty Liver Disease

Frontiers in Medicine
Jesús Funuyet-SalasManuel Romero-Gómez

Abstract

Background: It is unknown how perceived social support and the progression of liver damage influence the psychosocial profile of patients with non-alcoholic fatty liver disease (NAFLD). In the present study, we therefore investigated which biomarkers influence the quality of life, mental health, and coping strategies of NAFLD patients. Methods: Quality of life (SF-12 and CLDQ-NAFLD), mental health (HADS and BDI-II), and coping strategies (COPE-28) were evaluated by high or low perceived social support (MSPSS) and the presence of non-alcoholic steatohepatitis (NASH) and significant fibrosis in 492 biopsy-proven NAFLD patients. The results were compared with quality of life normality tables for the general Spanish population. We also determined whether liver histology and biopsychosocial variables predicted participants' quality of life. Results: Interactive effects were found in vitality (p = 0.05), activity (p = 0.005), anxiety (p = 0.04), and denial (p = 0.04), with NASH patients showing a higher-risk biopsychosocial profile when they perceived less social support. Furthermore, patients with low perceived social support showed lower quality of life, worse mental health, and more maladaptive coping than those with high perceive...Continue Reading

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Citations

Feb 5, 2021·Frontiers in Medicine·Ji Min ChoiJeong Yoon Yim
Apr 4, 2021·International Journal of Environmental Research and Public Health·Jesús Funuyet-SalasManuel Romero-Gómez

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Methods Mentioned

BETA
biopsy

Software Mentioned

SPSS Statistics
Quality Metric Health Outcomes TM Scoring Software

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