Psychological contributors to the frail phenotype: The association between resilience and frailty in patients with cirrhosis.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Randi J WongJennifer C Lai

Abstract

We examined whether a key psychological trait-resilience, defined as one's ability to recover quickly from difficulties-contributes to the frail phenotype in patients with cirrhosis. Included were 300 adult patients with cirrhosis who underwent outpatient physical frailty testing using the Liver Frailty Index and resilience testing using the Connor-Davidson Resilience Scale (CD-RISC). The Liver Frailty Index was categorized as robust, prefrail-robust, prefrail-frail, and frail; CD-RISC was categorized using population norms as: least, less, more, and most resilient. Linear regression was used to assess factors associated with frailty (by the Liver Frailty Index per 0.1 unit change). Among the most resilient, only 10% were frail; among the least resilient, 29% were frail. In univariable analysis, resilience was strongly associated with the Liver Frailty Index (coef = -0.13 per point increase; 95% confidence interval [CI], -0.20 to -0.60; P < .001) and remained significantly associated with frailty in multivariable adjustment (coef = -0.13, 95% CI -0.19 to -0.07; P < .001). Low resilience is strongly associated with the frail phenotype in patients with cirrhosis. Given that resilience is modifiable, our data suggest that effectiv...Continue Reading

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Nov 3, 2020·Digestive Diseases and Sciences·Elizabeth S AbySammy Saab
May 1, 2021·Life·Hiroki NishikawaKazuhide Higuchi
Apr 15, 2021·Current Opinion in Anaesthesiology·Ibukunoluwa Adeleke, Jeanna Blitz
Oct 12, 2021·International Psychogeriatrics·Axelle CostenobleUNKNOWN Gerontopole Brussels Study Group

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