Abstract
Stress-induced impairments of mucosal immunity may increase susceptibility to infectious diseases. The present study investigated the association of perceived stress, depressive symptoms, and loneliness with salivary levels of secretory immunoglobulin A (S-IgA), the subclasses S-IgA1, S-IgA2, and their transporter molecule Secretory Component (SC). S-IgA/SC, IgA1/SC and IgA2/SC ratios were calculated to assess the differential effects of stress on immunoglobulin transport versus availability. This study involved 113 university students, in part selected on high scores on the UCLA Loneliness Scale and/or the Beck Depression Inventory. Stress levels were assessed using the Perceived Stress Scale. Unstimulated saliva was collected and analysed for total S-IgA and its subclasses, as well as SC and total salivary protein. Multiple linear regression analyses, adjusted for gender, age, health behaviours, and concentration effects (total protein) revealed that higher perceived stress was associated with lower levels of IgA1 but not IgA2. Perceived stress, loneliness and depressive symptoms were all associated with lower IgA1/SC ratios. Surprisingly, higher SC levels were associated with loneliness and depressive symptoms, indicative of...Continue Reading
References
Dec 1, 1995·Journal of Immunological Methods·J W de FijterM R Daha
Apr 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·O CoqueretP Braquet
Sep 20, 1993·Annals of the New York Academy of Sciences·M Navazesh
Jun 21, 1996·Journal of Immunological Methods·J MesteckyC B Reimer
Aug 24, 1999·Immunology and Cell Biology·M GleesonR L Clancy
Jan 27, 2000·Critical Reviews in Immunology·I N NorderhaugP Brandtzaeg
Oct 2, 2001·Psychophysiology·J A BoschA V Amerongen
Jan 5, 2002·International Journal of Sports Medicine·D C NiemanS L Nehlsen-Cannarella
Mar 5, 2003·Brain, Behavior, and Immunity·Louise C Hawkley, John T Cacioppo
Oct 19, 2004·European Journal of Applied Physiology·E TiollierM Chennaoui
Jan 18, 2005·Biological Chemistry·Wijnand TeeuwArie V Nieuw Amerongen
Jul 26, 2005·Biological Psychology·Ivan NyklícekArie V Nieuw Amerongen
Aug 2, 2005·Brain, Behavior, and Immunity·Anna C PhillipsGeoff Der
Sep 27, 2005·Psychological Science·Louise C HawkleyJohn T Cacioppo
Apr 3, 2007·Psychosomatic Medicine·Janice K Kiecolt-GlaserRonald Glaser
Jun 26, 2007·Psychoneuroendocrinology·Adriana Jarillo-LunaRafael Campos-Rodríguez
Sep 4, 2007·Psychosomatic Medicine·Jos A BoschPhillip T Marucha
Aug 30, 2008·Biomedical Research·Koichi TakatsujiYukari Yamaguchi
Sep 30, 2008·European Journal of Oral Sciences·Alexandre MoreiraVera Cavalcanti de Araújo
Dec 17, 2008·Mucosal Immunology·A J MacphersonP Brandtzaeg
Dec 17, 2008·Mucosal Immunology·J R Mora, U H von Andrian
May 11, 2010·Immunological Investigations·Nicholas J Mantis, Stephen J Forbes
May 25, 2010·International Archives of Occupational and Environmental Health·Kyoung-Mu LeeJoseph J Hurrell
Jun 3, 2010·Neuroimmunomodulation·Nathália Matos-GomesMaria Cristina Dos-Santos
Aug 19, 2010·Psychosomatic Medicine·Anette PedersenDana H Bovbjerg
Oct 13, 2010·Immunology Letters·Rigoberto Oros-PantojaRafael Campos-Rodríguez
Apr 1, 1999·Environmental Health and Preventive Medicine·S Tsujita, K Morimoto
Apr 9, 2011·Journal of Science and Medicine in Sport·Elena Papacosta, George P Nassis
Sep 23, 2011·Mucosal Immunology·J M Woof, M W Russell
Nov 8, 2011·Physiology & Behavior·Ana F TruebaThomas Ritz
May 1, 2012·Current Opinion in Virology·Shintaro Sato, Hiroshi Kiyono
Feb 13, 2013·The British Journal of Nutrition·Patricia Castro-Sánchez, José M Martín-Villa
Mar 15, 2013·Journal of Oral Microbiology·Per Brandtzaeg
Citations
Nov 1, 2015·Brain, Behavior, and Immunity·Sally E Jensen
Apr 23, 2016·Acta Odontologica Scandinavica·Mette Rose JørgensenSvante Twetman
May 12, 2017·Brazilian Dental Journal·Otávio Pereira D'AvilaFernando Neves Hugo
Aug 8, 2017·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Pao-Ju ChenJen-Jiuan Liaw
Sep 12, 2017·Psychological Medicine·A Ulmer-YanivR Feldman
Nov 22, 2019·Journal of Applied Physiology·Nadia H AghaRichard J Simpson
Nov 2, 2019·Developmental Psychobiology·Charlotte C EllbergLeah C Hibel
May 1, 2020·International Journal of Environmental Research and Public Health·Frederick G B GoddardJoe Brown
Jan 30, 2019·Journal of Strength and Conditioning Research·Caoimhe TiernanGiles Warrington
Aug 23, 2018·International Journal of Behavioral Medicine·O KornienkoD A Granger
Nov 15, 2019·International Journal of Nursing Practice·Verena GebhartSusanne Perkhofer
May 2, 2018·Frontiers in Immunology·John P Campbell, James E Turner
Sep 13, 2019·Stomatologii︠a︡·D R AhmedbeyliR M Ahmedbeyli
Aug 20, 2017·Scientific Reports·Misaki WadaShigenobu Shibata
Sep 14, 2017·Journal of Strength and Conditioning Research·Anthony N TurnerLygeri Dimitriou
Jun 6, 2018·Biological Research for Nursing·Eileen M Condon
Jan 13, 2021·Developmental Psychobiology·Eyal AbrahamRuth Feldman
Feb 18, 2020·Brain, Behavior, and Immunity·Jordan N KohnSuzi Hong
Feb 5, 2021·Journal of Clinical Medicine·Sylwia ChojnowskaNapoleon Waszkiewicz
Mar 28, 2020·Current Opinion in Behavioral Sciences·Christopher G EngelandNicolas Rohleder
May 1, 2021·Journal of Clinical Medicine·Kacper Łoś, Napoleon Waszkiewicz
Aug 25, 2021·Scientific Reports·Patryk SteczHanna Misiołek
Nov 23, 2021·Research Quarterly for Exercise and Sport·Eleanor Perkins, Glen Davison