PMID: 3747845Jul 1, 1986Paper

Psychological effects of progestogens in the post-menopausal years

Maturitas
L Dennerstein, G D Burrows

Abstract

Progestogens are increasingly being advocated as a necessary and integral part of hormone replacement therapy. Yet few studies have measured the acceptability of these regimes. One factor profoundly affecting acceptability, and thus patient compliance, is the presence of adverse psychological effects of progestogens. There have been few double-blind trials which have evaluated such effects of progestogens and compared them with the effects of oestrogen administration alone. There is some evidence of less favourable effects when certain progestogens are added to oestrogen or used alone. Whilst the literature is limited there is an indication that adverse effects of progestogens may relate to dosage, type of progestogen and individual sensitivity of women to hormone provocation of symptoms. Further studies are needed to test these hypotheses.

References

Dec 4, 1975·The New England Journal of Medicine·H K Ziel, W D Finkle
Jun 1, 1979·Maturitas·L DennersteinK Sharpe
Jun 1, 1978·Maturitas·L Dennerstein, G D Burrows
Dec 4, 1975·The New England Journal of Medicine·D C SmithW L Herrmann
Jun 1, 1985·British Medical Journal·L DennersteinG D Burrows
Jan 1, 1974·Current Medical Research and Opinion·M AylwardR J Parker
Jul 19, 1980·British Medical Journal·G T BungayC K McPherson

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Citations

Oct 12, 1991·Lancet
Oct 1, 1992·Psychoneuroendocrinology·S M Phillips, B B Sherwin
Oct 23, 1997·Journal of Psychosomatic Research·A BakerD Dawson
Apr 3, 2001·BJOG : an International Journal of Obstetrics and Gynaecology·V NataleR Di Micco
Jun 1, 1997·Endocrinology and Metabolism Clinics of North America·T PearlsteinA B Stone
Aug 4, 2001·Psychosomatic Medicine·H B BosworthI C Siegler
Jan 27, 2005·Climacteric : the Journal of the International Menopause Society·I RudolphT Gräser
Mar 29, 2005·The American Journal of Orthopsychiatry·Kenneth E MillerAllison Goldman

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