Psychological Factors and Conditioned Pain Modulation: A Meta-Analysis

The Clinical Journal of Pain
Hadas Nahman-AverbuchDavid Yarnitsky

Abstract

Conditioned pain modulation (CPM) responses may be affected by psychological factors such as anxiety, depression, and pain catastrophizing; however, most studies on CPM do not address these relations as their primary outcome. The aim of this meta-analysis was to analyze the findings regarding the associations between CPM responses and psychological factors in both pain-free individuals and pain patients. After a comprehensive PubMed search, 37 articles were found to be suitable for inclusion. Analyses used DerSimonian and Laird's random-effects model on Fisher's z-transforms of correlations; potential publication bias was tested using funnel plots and Egger's regression test for funnel plot asymmetry. Six meta-analyses were performed examining the correlations between anxiety, depression, and pain catastrophizing, and CPM responses in healthy individuals and pain patients. No significant correlations between CPM responses and any of the examined psychological factors were found. However, a secondary analysis, comparing modality-specific CPM responses and psychological factors in healthy individuals, revealed the following: (1) pressure-based CPM responses were correlated with anxiety (grand mean correlation in original units r=...Continue Reading

References

Jun 1, 1987·The American Journal of Occupational Therapy : Official Publication of the American Occupational Therapy Association·K E Krauss
Dec 1, 1972·Postgraduate Medicine·A T Beck, R W Beck
Feb 13, 2004·Brain : a Journal of Neurology·R H GracelyD J Clauw
Apr 15, 2006·CNS & Neurological Disorders Drug Targets·P SokoloffC Gross
Nov 22, 2007·European Journal of Oral Sciences·Michele ShapiroShula Parush
Nov 22, 2007·Experimental Brain Research·Irit Weissman-FogelDorit Pud
Apr 9, 2008·Diabetes/metabolism Research and Reviews·Dan Ziegler
Apr 1, 2009·The Clinical Journal of Pain·Juliana Barcellos de SouzaSerge Marchand
May 1, 2009·Expert Review of Neurotherapeutics·Phillip J QuartanaRobert R Edwards
May 26, 2009·The Journal of Pain : Official Journal of the American Pain Society·Stéphane PotvinSerge Marchand
Nov 13, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mathieu PichéPierre Rainville
Jan 16, 2010·The Journal of Pain : Official Journal of the American Pain Society·Gerrit van Wijk, Dieuwke S Veldhuijzen
Mar 17, 2010·Pain·Antoinette I M van LaarhovenAndrea W M Evers
Mar 17, 2010·European Journal of Pain : EJP·David YarnitskyOliver Wilder-Smith
May 28, 2010·Journal of Pain & Palliative Care Pharmacotherapy·Oliver Hamilton Wilder-SmithLars Arendt-Nielsen
Sep 8, 2010·The Journal of Clinical Psychiatry·Edith NormandSerge Marchand
Dec 21, 2010·The Journal of Pain : Official Journal of the American Pain Society·Meyke RoosinkMaarten J Ijzerman
Feb 2, 2011·Nature Reviews. Rheumatology·Robert R EdwardsJennifer A Haythornthwaite
Feb 5, 2011·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Jan PraskoVladimir Mihal
Nov 4, 2011·Psychosomatic Medicine·Markus BurgmerBettina Pfleiderer

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Citations

Nov 12, 2015·Physiology & Behavior·Hadas Nahman-AverbuchGiris Jacob
Nov 26, 2016·The Journal of Pain : Official Journal of the American Pain Society·Sine SkovbjergThomas Graven-Nielsen
Feb 12, 2017·Journal of Applied Physiology·Matthew D JonesBenjamin K Barry
May 11, 2018·Pain·Estephan J Moana-FilhoNicole R Theis-Mahon
Oct 15, 2018·Pain Practice : the Official Journal of World Institute of Pain·Che-Sheng ChuPhilip Chik-Keung Chow
Sep 18, 2018·The Clinical Journal of Pain·Ségolène LithfousAndré Dufour
Jul 31, 2019·European Journal of Pain : EJP·Marie Udnesseter LieKristian Bernhard Nilsen
Feb 8, 2020·Haemophilia : the Official Journal of the World Federation of Hemophilia·Steffen Krüger, Thomas Hilberg
Jul 22, 2020·Scandinavian Journal of Pain·Lars Arendt-NielsenPascal Madeleine
Aug 28, 2016·Experimental Brain Research·Claudia Horn-HofmannStefan Lautenbacher
Dec 31, 2016·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Angelique G BrellenthinKelli F Koltyn
Nov 7, 2017·European Journal of Pain : EJP·L Arendt-NielsenA Mohr Drewes
Feb 6, 2019·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Matthias VogelSebastian Illiger
Oct 11, 2017·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Maaike Van Den HouteOmer Van den Bergh
Jun 27, 2018·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Josué Fernández-CarneroRoy La Touche
Feb 2, 2019·Pain Reports·Janne GierthmühlenRalf Baron
Aug 6, 2020·Scandinavian Journal of Pain·Jessica McDougallJohn L K Kramer
Aug 21, 2020·The Clinical Journal of Pain·Kasper S ChristensenThorvaldur S Palsson
Jan 4, 2021·European Archives of Paediatric Dentistry : Official Journal of the European Academy of Paediatric Dentistry·C A de Araújo VitorM T B R Santos
Sep 24, 2020·European Journal of Pain : EJP·Michel Gcam MertensMira Meeus
Jan 21, 2020·Journal of Affective Disorders·Noga TsurZahava Solomon
Jan 24, 2018·The Journal of Pain : Official Journal of the American Pain Society·Daniel E HarperSteven E Harte
Aug 18, 2020·Neurobiology of Disease·Julia ForstenpointnerDavid Borsook

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Software Mentioned

R meta - analysis package metaphor
Studio
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