Psychological impact of genetic testing for familial hypercholesterolemia within a previously aware population: a randomized controlled trial

American Journal of Medical Genetics. Part a
Theresa M MarteauGenetic Risk Assessment for FH Trial Study Group

Abstract

This trial tests the hypothesis that confirming a clinical diagnosis of familial hypercholesterolemia (FH) by finding a genetic mutation reduces patients' perceptions of control over the disease and adherence to risk-reducing behaviors. Three hundred forty-one families, comprising 341 hypercholesterolemia probands and 128 adult relatives, were randomized to one of two groups: (a) routine clinical diagnosis; (b) routine clinical diagnosis plus genetic testing (mutation searching in probands and direct gene testing in relatives). The main outcome measures were perceptions of control over hypercholesterolemia, adherence to cholesterol-lowering medication, diet, physical activity, and smoking. There was no support for the main hypothesis: finding a mutation had no impact on perceived control or adherence to risk-reducing behavior (all P-values > 0.10). While all groups believed that lowering cholesterol was an effective way of reducing the risk of a heart attack, participants in whom a mutation was found believed less strongly in the efficacy of diet in reducing their cholesterol level (P = 0.02 at 6 months) and showed a trend in believing more strongly in the efficacy of cholesterol-lowering medication (P = 0.06 at 6 months). In c...Continue Reading

References

May 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·P V KoivistoK Kontula
Sep 1, 1992·The British Journal of Clinical Psychology·T M Marteau, H Bekker
Aug 1, 1967·Journal of Chronic Diseases·D Schwartz, J Lellouch
Jun 1, 1983·Acta Psychiatrica Scandinavica·A S Zigmond, R P Snaith
Jan 1, 1997·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·C LermanN Caporaso
Oct 20, 2000·European Journal of Human Genetics : EJHG·M BroadstockT Marteau
Jul 10, 2001·Molecular Psychiatry·S TordjmanG M Anderson
Nov 22, 2001·Journal of the American Dietetic Association·J Harvey-BerinoE T Poehlman
Mar 19, 2002·American Journal of Preventive Medicine·Jennifer B McClure
Mar 1, 2002·Journal of Health Psychology·Victoria SeniorTheresa M Marteau

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Citations

Jan 4, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Steve E HumphriesAnthony S Wierzbicki
Mar 17, 2005·Cardiovascular Drugs and Therapy·Victoria SeniorUNKNOWN Genetic Risk Assessment for FH Trial (GRAFT) Study Group
Sep 20, 2007·Journal of General Internal Medicine·Winfried RiefJohannes Hebebrand
Mar 13, 2012·Genes & Nutrition·Daiva E Nielsen, Ahmed El-Sohemy
Oct 26, 2012·The Proceedings of the Nutrition Society·Jacqueline A Vernarelli
Jul 1, 2008·Psychology & Health·Martina Panzer, Britta Renner
Jul 2, 2005·Current Opinion in Lipidology·S Gaye Hadfield, Steve E Humphries
May 23, 2008·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Ruth CowanClara L Gaff
Jul 21, 2009·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Muin J KhouryUNKNOWN Centers for Disease Control and Prevention
Jul 9, 2008·Current Opinion in Lipidology·Steve E HumphriesDevikair Nair
May 22, 2008·International Journal of Clinical Practice·D P NichollsI S Young
Oct 17, 2007·Annual Review of Psychology·Howard LeventhalL Alison Phillips
Jan 17, 2012·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Jason L VassyRichard W Grant
Mar 5, 2010·The International Journal of Behavioral Nutrition and Physical Activity·Catharine Wang, Elliot J Coups
Apr 8, 2014·PloS One·Jenny E OstergrenJennifer B McCormick
Jan 15, 2014·Global Advances in Health and Medicine : Improving Healthcare Outcomes Worldwide·Allison A VorderstrasseRuth Q Wolever
Dec 10, 2013·Personalized Medicine·Kurt D Christensen, Robert C Green
Sep 4, 2014·Annual Review of Genomics and Human Genetics·J Scott RobertsBeth A Tarini
Jul 22, 2015·Journal of Atherosclerosis and Thrombosis·Raul D SantosAna P M Chacra
Mar 19, 2014·Journal of Clinical Lipidology·Gerald F WattsJohn J P Kastelein
Dec 10, 2013·Journal of Clinical Lipidology·W Virgil BrownJohn Kane
Apr 16, 2013·Progress in Neurobiology·J Scott Roberts, Wendy R Uhlmann
Sep 16, 2011·Atherosclerosis. Supplements·Gerald F WattsUNKNOWN Familial Hypercholesterolaemia Australasia Network Consensus Group (Australian Atherosclerosis Society)
May 27, 2011·Journal of Clinical Lipidology·Paul N HopkinsUNKNOWN National Lipid Association Expert Panel on Familial Hypercholesterolemia
Apr 23, 2010·American Journal of Preventive Medicine·Colleen M McBrideThomas W Valente
Jul 3, 2007·Patient Education and Counseling·Ellen SmetsSusan Michie
May 7, 2005·Risk Analysis : an Official Publication of the Society for Risk Analysis·Theresa M MarteauRobert C Green

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