Psychological Interventions for Vaccine Injections in Children and Adolescents: Systematic Review of Randomized and Quasi-Randomized Controlled Trials

The Clinical Journal of Pain
Kathryn A BirnieHELPinKids&Adults Team

Abstract

This systematic review evaluated the effectiveness of psychological interventions for reducing vaccination pain and related outcomes in children and adolescents. Database searches identified relevant randomized and quasi-randomized controlled trials. Data were extracted and pooled using established methods. Pain, fear, and distress were considered critically important outcomes. Twenty-two studies were included; 2 included adolescents. Findings showed no benefit of false suggestion (n=240) for pain (standardized mean difference [SMD] -0.21 [-0.47, 0.05]) or distress (SMD -0.28 [-0.59, 0.11]), or for use of repeated reassurance (n=82) for pain (SMD -0.18 [-0.92, 0.56]), fear (SMD -0.18 [-0.71, 0.36]), or distress (SMD 0.10 [-0.33, 0.54]). Verbal distraction (n=46) showed reduced distress (SMD -1.22 [-1.87, -0.58]), but not reduced pain (SMD -0.27 [-1.02, 0.47]). Similarly, video distraction (n=328) showed reduced distress (SMD -0.58 [-0.82, -0.34]), but not reduced pain (SMD -0.88 [-1.78, 0.02]) or fear (SMD 0.08 [-0.25, 0.41]). Music distraction demonstrated reduced pain when used with children (n=417) (SMD -0.45 [-0.71, -0.18]), but not with adolescents (n=118) (SMD -0.04 [-0.42, 0.34]). Breathing with a toy (n=368) showed bene...Continue Reading

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Citations

Oct 5, 2018·The Cochrane Database of Systematic Reviews·Kathryn A BirnieJennifer A Parker
May 18, 2018·Archives of Disease in Childhood·Netty G P Bos-VenemanSijmen A Reijneveld
Jul 23, 2015·The Clinical Journal of Pain·Rebecca Pillai RiddellUNKNOWN HELPinKIDS&Adults Team
Sep 10, 2015·The Clinical Journal of Pain·Anna TaddioUNKNOWN HELPinKids&Adults Team
Jan 1, 2017·Journal of Cognitive Psychotherapy·C Meghan McMurtryLara M Genik
Sep 10, 2015·The Clinical Journal of Pain·C Meghan McMurtryUNKNOWN HELPinKids&Adults Team
Mar 8, 2021·International Journal of Pharmaceutics·Álvaro Cárcamo-MartínezRyan F Donnelly
Apr 8, 2021·Clinical and Experimental Dental Research·Soma Arabzade MoghadamSahand Saad

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Methods Mentioned

BETA
medical procedure
profiler

Software Mentioned

GRADE
RevMan
GRADE profiler

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