Psychological mediators of the association between childhood adversities and psychosis: A systematic review

Clinical Psychology Review
Jessica WilliamsFilippo Varese

Abstract

This is the first review to identify, summarise and critically evaluate studies that examined psychological mediators of the relationship between childhood adversities and psychosis. A database search (PsychINFO, MEDLINE, Web of Science, CINAHL) was conducted to identify eligible studies published between January 1980 and September 2017. A narrative synthesis and appraisal of methodological quality and statistical appropriateness of the primary studies was conducted. We identified 37 papers, comprising 9057participants with psychotic disorders and 63,059 non-clinical participants. Despite great variation in the mediators considered and the methodological and analytic quality of the primary studies, our synthesis suggests that the relationship between childhood adversity and psychosis is mediated by several "families" of mediating variables including post-traumatic sequelae (e.g. dissociation, PTSD symptoms), affective dysfunction and dysregulation, and maladaptive cognitive factors (e.g. self-esteem and beliefs and concepts about the self and others). More tentative evidence was observed for the role played by appraisals of subsequent circumstantial factors (e.g. "life hassles"). Substance misuse was not found to be a prominent...Continue Reading

Citations

Feb 7, 2020·Psychological Medicine·Elaine M McMahonMary Cannon
Apr 7, 2020·Schizophrenia Bulletin·Eleanor LongdenFilippo Varese
May 22, 2020·Psychology and Psychotherapy·Rachel M BrandNeil Thomas
Jul 8, 2020·International Journal of Environmental Research and Public Health·Sandra Fernández-LeónCristina Senín-Calderón
Feb 6, 2020·The British Journal of Clinical Psychology·Jane SimpsonPhilip Powell
May 15, 2020·European Child & Adolescent Psychiatry·Christian RauschenbergUlrich Reininghaus
May 14, 2019·Frontiers in Psychology·Benedetto FarinaClaudio Imperatori
Oct 22, 2019·Development and Psychopathology·Katie Aafjes-van DoornGeorge Silberschatz
Dec 15, 2020·Psychological Medicine·Daniela StrelchukStanley Zammit
Jan 13, 2021·Journal of Trauma & Dissociation : the Official Journal of the International Society for the Study of Dissociation (ISSD)·Lena MarsdenFilippo Varese
Jan 13, 2021·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Michael A P BloomfieldGlyn Lewis
Nov 12, 2019·Child and Adolescent Psychiatric Clinics of North America·Kate J StantonYael Dvir
Sep 26, 2020·Psychology, Health & Medicine·Tânia Brandão
Dec 17, 2021·Frontiers in Psychiatry·Carolina CampodonicoFilippo Varese

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