Abstract
This is the first review to identify, summarise and critically evaluate studies that examined psychological mediators of the relationship between childhood adversities and psychosis. A database search (PsychINFO, MEDLINE, Web of Science, CINAHL) was conducted to identify eligible studies published between January 1980 and September 2017. A narrative synthesis and appraisal of methodological quality and statistical appropriateness of the primary studies was conducted. We identified 37 papers, comprising 9057participants with psychotic disorders and 63,059 non-clinical participants. Despite great variation in the mediators considered and the methodological and analytic quality of the primary studies, our synthesis suggests that the relationship between childhood adversity and psychosis is mediated by several "families" of mediating variables including post-traumatic sequelae (e.g. dissociation, PTSD symptoms), affective dysfunction and dysregulation, and maladaptive cognitive factors (e.g. self-esteem and beliefs and concepts about the self and others). More tentative evidence was observed for the role played by appraisals of subsequent circumstantial factors (e.g. "life hassles"). Substance misuse was not found to be a prominent...Continue Reading
Citations
Feb 7, 2020·Psychological Medicine·Elaine M McMahonMary Cannon
Jan 8, 2020·Journal of Clinical Psychology·Jianlin LiuRathi Mahendran
Apr 7, 2020·Schizophrenia Bulletin·Eleanor LongdenFilippo Varese
May 22, 2020·Psychology and Psychotherapy·Rachel M BrandNeil Thomas
May 3, 2020·Clinical Psychology & Psychotherapy·Jianlin LiuRathi Mahendran
Jul 8, 2020·International Journal of Environmental Research and Public Health·Sandra Fernández-LeónCristina Senín-Calderón
Jul 7, 2020·Psychological Medicine·Lucia SideliHelen L Fisher
Feb 6, 2020·The British Journal of Clinical Psychology·Jane SimpsonPhilip Powell
May 18, 2019·Early Intervention in Psychiatry·Dagmara MętelŁukasz Gawęda
Aug 4, 2020·Psychological Medicine·Luis AlamedaRobin M Murray
Sep 12, 2020·Psychology and Psychotherapy·Filippo VareseDouglas Turkington
May 15, 2020·European Child & Adolescent Psychiatry·Christian RauschenbergUlrich Reininghaus
May 14, 2019·Frontiers in Psychology·Benedetto FarinaClaudio Imperatori
Oct 22, 2019·Development and Psychopathology·Katie Aafjes-van DoornGeorge Silberschatz
Dec 15, 2020·Psychological Medicine·Daniela StrelchukStanley Zammit
Jan 13, 2021·Journal of Trauma & Dissociation : the Official Journal of the International Society for the Study of Dissociation (ISSD)·Lena MarsdenFilippo Varese
Jan 13, 2021·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Michael A P BloomfieldGlyn Lewis
Apr 17, 2020·Schizophrenia Research·Tamara SheinbaumNeus Barrantes-Vidal
Nov 12, 2019·Child and Adolescent Psychiatric Clinics of North America·Kate J StantonYael Dvir
Nov 24, 2020·Early Intervention in Psychiatry·Filippo VareseRichard Bentall
Dec 29, 2020·Early Intervention in Psychiatry·Rodolfo RossiFrancesca Pacitti
Feb 12, 2020·Psychiatry Research·Rachel M BrandNeil Thomas
Feb 28, 2021·European Child & Adolescent Psychiatry·Berhe W SahleAnthony F Jorm
Mar 3, 2021·Psychological Medicine·Supriya MisraCraig Morgan
Sep 26, 2020·Psychology, Health & Medicine·Tânia Brandão
Jul 3, 2021·Schizophrenia Research·Paul J RosenfieldLuca Pauselli
Aug 21, 2021·Psychological Medicine·Judith AllardyceStan Zammit
Dec 17, 2021·Frontiers in Psychiatry·Carolina CampodonicoFilippo Varese