Psychological morbidity in women at increased risk of developing breast cancer: a controlled study

Psycho-oncology
Phyllis ButowKathleen Cuningham Consortium for Research into Familial Breast Cancer Psychosocial Group

Abstract

There has been an ongoing debate in the literature on the extent to which women with a family history of breast cancer are at risk of psychological morbidity. This study compares psychological morbidity in 557 women participating in a large Australian registry of high-risk breast cancer families (kConFab) with 2 age and education matched samples, 1494 general practitioner attendees and 158 members of a twin registry. Participants completed the Somatic and Psychological Health Report (SPHERE). There were no significant differences between the three groups on psychological distress (F(2, 670) = 1.77, p = 0.17). Unsurprisingly, GP attendees reported more symptoms of somatic distress than the kConFab group (t411 = 2.89, p = 0.004); there were no differences between the twins and the kConFab group on somatic distress (t174 = 0.40, p = 0.687). Clinically significant anxiety/depression, a combination of psychological and somatic distress, therefore was significantly higher in GP attendees (28%) than the kConFab and twin samples (both 20%). These results refute the hypothesis that women with a family history of breast cancer are at greater psychological risk.

References

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Citations

Jan 12, 2010·Breast Cancer Research and Treatment·Colin Mooney, Sofia Merajver
Sep 11, 2007·Journal of Genetic Counseling·Melanie Anne PriceUNKNOWN Kathleen Cuningham Consortium for Research into Familial Breast Cancer (kConFab) Psychosocial Group
Apr 22, 2011·Journal of Genetic Counseling·Tara E PowerDawna M Gilchrist
Jun 28, 2012·Journal of Genetic Counseling·Yael R CukierHeiddis B Valdimarsdottir
Feb 19, 2010·Palliative & Supportive Care·David K Wellisch, Marie M Cohen
Nov 29, 2012·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Nathan A GillespieIan B Hickie
Mar 2, 2006·Breast Cancer Research : BCR·Graham J MannUNKNOWN Kathleen Cuningham Consortium for Research in Familial Breast Cancer
May 25, 2006·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Kenneth E FletcherJane G Zapka
Oct 27, 2006·Social Science & Medicine·Carolyn RabinPeter C Trask
Mar 5, 2015·Journal of Genetic Counseling·Louise HeinigerUNKNOWN kConFab Psychosocial Group on behalf of the kConFab Investigators
Sep 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sally TyndelEila K Watson
Oct 14, 2017·Hereditary Cancer in Clinical Practice·Sara MellaMaria Antonietta Annunziata

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