PMID: 6410394Jul 1, 1983Paper

Psychological stress activates phosphorylase in the heart of the conscious pig without increasing heart rate and blood pressure

Proceedings of the National Academy of Sciences of the United States of America
J E SkinnerM L Entman

Abstract

The present study uses a technique that enables the collection of multiple freeze-biopsy samples from the myocardium of the conscious pig (i.e., through a thoracic window). This technique enables sequential analysis of the metabolic state of the myocardium during different behavioral conditions. The results demonstrate that with daily adaptations to an unfamiliar environment (i.e., stress reduction), the phosphorylase activation ratio (phosphorylase a/total phosphorylase) in the quiescent pig declines steadily from approximately 80% to 30% (r = -0.91, P less than 0.01). This decline occurs with both the mean resting heart rate and left ventricular blood pressure remaining constant. The decline is seen within individual subjects during the whole adaptation sequence as well as between subjects whose samples were taken either early or late in the adaptation series. The dissociation of hemodynamic functional and metabolic activation in the unadapted, psychologically stressed pig may be associated with the occurrence of increased vulnerability of the ischemic heart to ventricular fibrillation, a phenomenon previously observed under the same behavioral conditions.

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Citations

Oct 1, 1991·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·J E Skinner
Oct 1, 1994·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·G Dotevall
Dec 28, 1987·The American Journal of Cardiology·G W ParkerM L Entman
Jun 1, 1985·Journal of the American College of Cardiology·J E Skinner
Nov 13, 2007·Journal of Biomedical Optics·Qin HuangPeter J Hornsby
Jun 13, 2014·Journal of the Mechanical Behavior of Biomedical Materials·Siobhan A O'LearyTim M McGloughlin
Oct 31, 1989·Biochemical and Biophysical Research Communications·M L LenzJ R Mitchell

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