Psychological symptoms and insulin sensitivity in adolescents.

Pediatric Diabetes
Lauren B ShomakerJack A Yanovski

Abstract

Symptoms of psychological distress have been linked to low insulin sensitivity in adults; however, little is known about this relationship in pediatric samples. We therefore examined symptoms of depression and anxiety in relation to insulin sensitivity in adolescents. Participants were 136 non-treatment-seeking, healthy adolescents (53.2% female) of all weight strata (BMI-z = 1.08 +/- 1.08) between the ages of 12 and 18 years (M = 15.16,SD = 1.55). Adolescents completed questionnaire measures assessing depression and anxiety symptoms. Fasting blood samples for serum insulin and plasma glucose were obtained to estimate insulin sensitivity with the quantitative insulin sensitivity check index. Fat mass and fat-free mass were measured with air displacement plethysmography or dual-energy X-ray absorptiometry. Depressive symptoms were associated with higher fasting insulin and decreased insulin sensitivity even after controlling for fat mass, fat-free mass, height, age, pubertal status, race, and sex (p < 0.01). As has been described for adults, depressive symptoms are associated with low insulin sensitivity among healthy adolescents. Further experimental and prospective studies are required to determine the directionality of this l...Continue Reading

References

Apr 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·J H WrightR A Bell
Mar 1, 1988·The American Journal of Psychiatry·A WinokurJ D Amsterdam
Nov 1, 1988·Journal of the American Academy of Child and Adolescent Psychiatry·E J Costello, A Angold
Dec 1, 1986·Journal of Abnormal Child Psychology·A E KazdinA Rodgers
Feb 1, 1970·Archives of Disease in Childhood·W A Marshall, J M Tanner
Jun 1, 1969·Archives of Disease in Childhood·W A Marshall, J M Tanner
Feb 1, 1981·Nutrition Reviews·J M Tanner
Sep 1, 1995·Preventive Medicine·N Ravaja, L Keltikangas-Järvinen
Dec 1, 1996·Metabolism: Clinical and Experimental·K RäikkönenA Hautanen
May 26, 2001·Diabetes Care·R J AndersonP J Lustman
Dec 19, 2002·Metabolism: Clinical and Experimental·Katri RäikkönenLewis H Kuller
Jun 7, 2003·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Katri RäikkönenKristen Salomon
Aug 2, 2003·Biological Psychiatry·Dominique L MusselmanLawrence S Phillips
Jan 15, 2004·The Journal of Pediatrics·Neslihan GungorSilva Arslanian
Jun 4, 2004·The New England Journal of Medicine·Ram WeissSonia Caprio
Mar 17, 2006·Journal of Pediatric Gastroenterology and Nutrition·Delphine R RobothamJack A Yanovski
Jul 19, 2006·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Edward C Suarez
Jul 26, 2006·Journal of the American Academy of Child and Adolescent Psychiatry·Katholiki GeorgiadesJohn R Seeley
Sep 1, 2007·International Journal of Pediatric Obesity : IJPO : an Official Journal of the International Association for the Study of Obesity·Joey C EisenmannSteven N Blair
Dec 7, 2007·Annals of Clinical Psychiatry : Official Journal of the American Academy of Clinical Psychiatrists·Roger S McIntyreSidney H Kennedy
Jun 19, 2008·JAMA : the Journal of the American Medical Association·Sherita Hill GoldenConstantine Lyketsos

❮ Previous
Next ❯

Citations

Jan 22, 2013·Molecular Neurobiology·Rasoul GhasemiAbolhassan Ahmadiani
Mar 2, 2013·The Journal of Clinical Endocrinology and Metabolism·Diane C Adler-WailesJack A Yanovski
Jun 28, 2014·Journal of Neuroimmunology·Lindsay J SpielmanAndis Klegeris
Dec 29, 2015·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Natasha A SchveyJack A Yanovski
Oct 9, 2015·Annals of the New York Academy of Sciences·Tamara S Hannon, Silva A Arslanian
Apr 5, 2013·Pediatric Diabetes·Tamara S HannonSilva A Arslanian
Dec 9, 2014·Diabetes, Obesity & Metabolism·M A AdeyemoJ A Yanovski
Feb 21, 2014·Pediatric Diabetes·Alison N JefferyTerence J Wilkin
May 9, 2015·The International Journal of Eating Disorders·Natasha A SchveyMarian Tanofsky-Kraff
Feb 17, 2015·Molecular Metabolism·Angie C N ChongLori M Zeltser
Jun 24, 2016·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Lauren B ShomakerJack A Yanovski
Apr 4, 2017·The International Journal of Eating Disorders·Natasha L BurkeJack A Yanovski
Oct 20, 2018·Journal of Pediatric Psychology·Meghan E ByrneJack A Yanovski
Nov 7, 2019·Psychology, Health & Medicine·Lauren B ShomakerJack A Yanovski
Sep 15, 2015·Psychosomatic Medicine·Lauren B Shomaker, Elizabeth Goodman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.