Psychological therapies for treatment-resistant depression in adults.

The Cochrane Database of Systematic Reviews
Sharea IjazNicola Wiles

Abstract

Antidepressants are a first-line treatment for adults with moderate to severe major depression. However, many people prescribed antidepressants for depression don't respond fully to such medication, and little evidence is available to inform the most appropriate 'next step' treatment for such patients, who may be referred to as having treatment-resistant depression (TRD). National Institute for Health and Care Excellence (NICE) guidance suggests that the 'next step' for those who do not respond to antidepressants may include a change in the dose or type of antidepressant medication, the addition of another medication, or the start of psychotherapy. Different types of psychotherapies may be used for TRD; evidence on these treatments is available but has not been collated to date.Along with the sister review of pharmacological therapies for TRD, this review summarises available evidence for the effectiveness of psychotherapies for adults (18 to 74 years) with TRD with the goal of establishing the best 'next step' for this group. To assess the effectiveness of psychotherapies for adults with TRD. We searched the Cochrane Common Mental Disorders Controlled Trials Register (until May 2016), along with CENTRAL, MEDLINE, Embase, and P...Continue Reading

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Citations

Dec 18, 2019·The Cochrane Database of Systematic Reviews·Philippa DaviesNicola Wiles
Jan 11, 2020·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Pim CuijpersToshi A Furukawa
Jan 18, 2020·Aging & Mental Health·Mercy Ngosa MumbaRebecca S Allen
Oct 23, 2019·Depression and Anxiety·Bradley N GaynesKathleen N Lohr
Jul 16, 2020·Current Psychiatry Reports·Olivia E BoguckiCraig N Sawchuk
Jan 29, 2019·Frontiers in Psychiatry·Martino Belvederi MurriMario Amore
Oct 13, 2020·Zeitschrift für Gerontologie und Geriatrie·Anne GöhnerSebastian Voigt-Radloff
Apr 4, 2021·International Journal of Environmental Research and Public Health·Antonia Raya-TenaMaría Francisca Jiménez-Herrera
Jun 22, 2021·Computer Supported Cooperative Work : CSCW : an International Journal·Emily G LattieMadhu Reddy

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