Psychometric and utility-based measures of health status of asthmatic patients with different disease control level

PharmacoEconomics
Agota SzendeGyula Y Berta

Abstract

To explore the relationship between asthma control level and health-related QOL (HR-QOL), and to understand the role of various psychometric and utility-based methods in studying this relationship. Two hundred and twenty-eight consecutive adult outpatients and inpatients at four sites participated in the study. Physicians identified the level of disease control according to the Global Initiative for Asthma (GINA) classification system. Patients filled in three different HR-QOL questionnaires (EuroQol 5-D [EQ-5D], Short-Form 36-item health survey [SF-36], and St George's Respiratory Questionnaire [SGRQ]) and a direct time trade-off question. The Short Form-6D (SF-6D) was used to derive utility values from SF-36 data. All patient-reported evaluation methods could discriminate between patients with different disease control levels, and both generic and disease-specific instruments strongly correlated to each other. The magnitude of differences in HR-QOL between groups with different disease control levels was clinically meaningful. All three HR-QOL measures reflected a relationship between disease control level and HR-QOL, but the actual pattern of the relationship depended on the instrument used. Utilities gained from the EQ-5D i...Continue Reading

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