Psychometric evaluation of the EORTC QLQ-PR25 questionnaire in assessing health-related quality of life in prostate cancer survivors: a curate's egg

Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation
Eamonn O'LearyLinda Sharp

Abstract

The EORTC QLQ-PR25 was primarily developed to measure disease-specific health-related quality of life (HRQoL) of prostate cancer (PCa) patients undergoing active treatment. The growing number of cancer survivors has focussed interest on assessing survivors' HRQoL. We evaluated psychometric properties of the EORTC QLQ-PR25 questionnaire amongst PCa survivors. A postal questionnaire, including the QLQ-PR25, was administered to 6559 PCa survivors 2-18 years post-diagnosis, identified through population-based cancer registries in Ireland; 3348 participated. The QLQ-PR25 has been suggested to have five multi-item subscales measuring urinary (US), bowel (BS) and hormone treatment-related symptoms (TS), sexual activity (SA) and sexual functioning (SF), and a single item measuring bother due to using incontinence aids (IA). Reliability analysis, divergent validity, discriminant validity (compared to EORTC QLQ-C30, DASS-21 and EuroQoL EQ-5D-5L), and exploratory and confirmatory factor analysis (EFA, CFA) were undertaken. The percentage of survivors completing QLQ-PR25 subscales was: US-79 %; IA-20 %; BS-83 %; TS-86 %; SA-87 %; and SF-26 %. Reliability was acceptable (Cronbach's α > 0.7) for three subscales (US, SA, SF). The instrument d...Continue Reading

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Citations

May 12, 2017·Health and Quality of Life Outcomes·Marieke van LeeuwenUNKNOWN and the NCRN Testis Clinical Studies Group
Dec 6, 2018·International Journal of Urology : Official Journal of the Japanese Urological Association·Xue-Fei DingYang Luan
Apr 27, 2017·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Jens KleinOlaf von dem Knesebeck
Jan 11, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Rebecca MaguireLinda Sharp
Sep 26, 2020·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Sharon Odeo, Amsalu Degu
Dec 8, 2020·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·You-Shan FengInes Buchholz
Jun 19, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Melanie M A LindenbergWim W H van Harten

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