Psychometric evaluation of the myasthenia gravis composite using Rasch analysis

Muscle & Nerve
Reza SadjadiMG Composite MG-QOL15 Study Group

Abstract

The MG Composite (MGC) is a validated outcome measure of the clinical manifestations of myasthenia gravis. We performed Rasch analyses of the MGC to investigate additional properties, including its unidimensionality and the appropriateness of the weights assigned to the response categories for the MGC items. The fit statistics indicated that the 10 items belong together and can be summated for a total score. There was an overall absence of item order distortion between response categories. The Rasch model's expected category response values were compatible with item weights previously assigned. Our analysis suggests that: (1) the score can be summated to estimate an overall disease severity score; (2) the response options of the 10 items are not significantly distorted; and (3) the assigned weights of the response options are appropriate.

Associated Clinical Trials

References

Oct 1, 1990·Journal of Neurology·R MantegazzaP Tonali
Nov 1, 1964·Journal of the Neurological Sciences·H J OOSTERHUIS
Jan 7, 2004·Medical Care·Colleen A McHorney, Patrick O Monahan
Dec 7, 2007·Muscle & Nerve·David GrobMurali Pagala
Nov 20, 2008·Muscle & Nerve·Ted M BurnsUNKNOWN Muscle Study Group
May 5, 2010·Neurology·Ted M BurnsUNKNOWN MG Composite and MG-QOL15 Study Group
Feb 8, 2011·Lancet·Matthew C KiernanMargaret C Zoing
Jul 5, 2011·Current Opinion in Neurology·Mamede de Carvalho, Michael Swash

❮ Previous
Next ❯

Citations

Nov 16, 2013·The International Journal of Neuroscience·Alessandra AriattiGiuliana Galassi
Sep 16, 2015·Muscle & Nerve·Carlo AntozziRenato Mantegazza
Feb 19, 2014·Muscle & Nerve·Kimiaki UtsugisawaNorihiro Suzuki
Nov 1, 2016·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Pushpa Narayanaswami
Dec 3, 2016·Arquivos de neuro-psiquiatria·Ezequiel Fernandes OliveiraLuis Vicente Franco Oliveira
Sep 26, 2020·Dementia & Neuropsychologia·Annelise AyresMaira Rozenfeld Olchik
Sep 2, 2015·Journal of Neuromuscular Diseases·Carolina BarnettVera Bril
Jul 27, 2017·Arquivos de neuro-psiquiatria·Ezequiel Fernandes OliveiraLuis Vicente Franco Oliveira
Feb 22, 2017·Journal of Clinical Neuromuscular Disease·Srikanth Muppidi
Jan 24, 2017·The New England Journal of Medicine·Joseph B Shrager
Oct 28, 2020·Logopedics, Phoniatrics, Vocology·Annelise AyresMaira Rozenfeld Olchik

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Muscle & Nerve
Srikanth MuppidiMG Composite and MG-QOL15 Study Group
Annals of the New York Academy of Sciences
Fulvio BaggiDonald B Sanders
Annals of the New York Academy of Sciences
C A ElechiR P Lisak
© 2021 Meta ULC. All rights reserved