Psychomotor slowing in HIV infection: a predictor of dementia, AIDS and death

Journal of Neurovirology
Ned SacktorJ C McArthur

Abstract

The objective of this study was to determine if sustained decline in psychomotor speed tests is associated with an increased risk of progression to dementia, acquired immunodeficiency syndrome (AIDS), or mortality in human immunodeficiency virus (HIV)-1-infected homosexual men in the Baltimore site of the Multicenter AIDS Cohort-Study (MACS). Clinical and neuropsychological data were obtained on 291 HIV+ homosexual men seen semi-annually over a nine year period (1986-1994). A proportional hazards model was used to assess the predictive value of sustained psychomotor slowing (defined as a 2.0 standard deviation (s.d.) decline in performance on either the Symbol Digit Modalities test or Trailmaking test at two consecutive evaluations). Time-dependent co-variates included in the model were sustained psychomotor slowing, number of attended visits, CD4+ lymphocyte count, hemoglobin and antiretroviral medication use. HIV+ participants with and without sustained psychomotor slowing were compared. Outcome variables were the development of dementia, AIDS and death. HIV+ subjects with sustained psychomotor slowing had an increased hazard of dementia (Risk ratio (RR) = 5.0, P = 0.008), AIDS (RR = 2.4, P = 0.02), and death (RR = 2.0, P = 0...Continue Reading

Citations

Mar 8, 2005·Journal of Neurology·Hans-Jürgen von GiesenGabriele Arendt
May 9, 2009·Neuropsychology Review·Lucette A Cysique, Bruce J Brew
Dec 11, 2008·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Bruce J BrewGilles Guillemin
Oct 30, 2008·Current Neurology and Neuroscience Reports·Beau M Ances, David B Clifford
Mar 14, 2013·Journal of Neurovirology·Thep ChalermchaiUNKNOWN SEARCH 007 and 011 study groups
Mar 27, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·D M Rausch, E S Stover
Feb 22, 2003·European Journal of Radiology·Edith V Sullivan, Adolf Pfefferbaum
Aug 15, 2006·Journal of the International Neuropsychological Society : JINS·Lucette A J CysiqueBruce J Brew
Oct 24, 2002·The American Journal of Nursing·Patrick J CoyneAshby C Watson
Jun 5, 2002·AIDS·Glenn J Treisman, Adam I Kaplin
Mar 20, 2010·AIDS·Lucette A CysiqueUNKNOWN HIV Neurobehavioral Research Center group
Apr 14, 2007·The Journal of Neuropsychiatry and Clinical Neurosciences·Bruce ShiramizuVictor Valcour
Aug 24, 2010·Journal of Neurovirology·Ned SacktorUNKNOWN Multicenter AIDS Cohort Study (MACS)
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·T F HornH S Fox
Jun 19, 2014·Current Neurology and Neuroscience Reports·Bruce J Brew, Phillip Chan
Sep 1, 2012·Revista colombiana de psiquiatría·Jorge Andrés Delgado de BedoutVíctor Daniel Calvo
Oct 22, 2008·Critical Care Clinics·Stephen J Ferrando, Zachary Freyberg
Dec 8, 2004·Journal of Neuroimmunology·Justin C McArthur
Oct 13, 2006·NeuroImage·Ming-Chang ChiangPaul M Thompson
Nov 22, 2005·Neurobiology of Disease·Gareth Jones, Christopher Power
Nov 5, 2005·Neuroscience Letters·Británico González-LiraOscar Prospéro-García
Jan 26, 2006·The Journal of the Association of Nurses in AIDS Care : JANAC·Charles RainesGlenn J Treisman
Aug 20, 2005·Lancet Neurology·Justin C McArthurAvi Nath
Feb 3, 2015·Annals of Clinical and Translational Neurology·Ann B RaginLeon G Epstein
Sep 10, 2016·African Journal of Primary Health Care & Family Medicine·Rachael N KinuthiaJoseph M Thigiti
Jan 7, 1999·São Paulo Medical Journal = Revista Paulista De Medicina·Y D FragosoC A Tavares
Dec 13, 2006·Journal of Clinical and Experimental Neuropsychology·Thomas D ParsonsKevin Robertson
Jan 15, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Hans-Jürgen von GiesenGabriele Arendt
Jun 7, 2007·Alcoholism, Clinical and Experimental Research·Stephanie A SassoonEdith V Sullivan

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