PMID: 8947933Nov 1, 1996Paper

Psychomotor stimulant- and opiate-induced c-fos mRNA expression patterns in the rat forebrain: comparisons between acute drug treatment and a drug challenge in sensitized animals

Neurochemical Research
E J CurranS J Watson

Abstract

Amphetamine-, cocaine-, and morphine-induced c-fos expression patterns were examined following an injection protocol that has previously been shown to produce behavioral sensitization and enhanced dopamine release in the striatal complex. Drug-specific c-fos patterns were observed in both acute and sensitization injection paradigms. A sensitization pretreatment schedule did, however, alter the c-fos expression patterns induced by all the drugs in the caudate putamen, nucleus accumbens, and the cerebral cortex. In some striatal and cortical regions, there was an increase or recruitment of cells expressing c-fos whereas in others there was an apparent decrease or inhibition. The somatosensory cortex was one area where pretreatment with all three drugs increased c-fos expression. The results suggest that the neuronal networks that are modulated by systemic drug injections in the sensitized animal differ from those affected by the initial drug exposure; areas of overlap may indicate common "sensitization' circuits.

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Citations

Mar 23, 2004·European Journal of Pharmacology·Ana González-CuelloM Luisa Laorden
Apr 30, 2013·European Journal of Pharmacology·Emilie BelkaïCynthia Marie-Claire
May 18, 2000·Brain Research. Molecular Brain Research·M Erdtmann-VourliotisV Höllt
Sep 13, 2002·Brain Research. Molecular Brain Research·P MayerV Höllt
Oct 31, 1998·Brain Research. Molecular Brain Research·M Erdtmann-VourliotisV Höllt
Oct 16, 1999·Brain Research. Molecular Brain Research·M Erdtmann-VourliotisV Höllt
Jan 3, 2003·Neurochemistry International·Desanka MilanovićSabera Ruzdijić
Aug 26, 1998·Drug and Alcohol Dependence·F J White, P W Kalivas
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Feb 14, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Pilar AlmelaM Luisa Laorden
Sep 28, 2014·Expert Opinion on Drug Discovery·Ashish P Vartak
Oct 23, 2012·Progress in Neurobiology·Heinz Steiner, Vincent Van Waes
Nov 22, 2011·Behavioural Brain Research·David L Wolgin
Jun 2, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ewa TarachaAdam Płaźnik
Jul 8, 2008·Journal of Neuroendocrinology·K J Kovács
Mar 4, 2008·The European Journal of Neuroscience·Anna R CartaGaetano Di Chiara
Apr 29, 2011·Brain Research Bulletin·Leah DziopaThomas I Nathaniel
Jan 11, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ewa TarachaStanisław J Chrapusta

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