Psychomotor symptoms of schizophrenia map on the cerebral motor circuit

Psychiatry Research
Sebastian Walther

Abstract

Schizophrenia is a devastating disorder thought to result mainly from cerebral pathology. Neuroimaging studies have provided a wealth of findings of brain dysfunction in schizophrenia. However, we are still far from understanding how particular symptoms can result from aberrant brain function. In this context, the high prevalence of motor symptoms in schizophrenia such as catatonia, neurological soft signs, parkinsonism, and abnormal involuntary movements is of particular interest. Here, the neuroimaging correlates of these motor symptoms are reviewed. For all investigated motor symptoms, neural correlates were found within the cerebral motor system. However, only a limited set of results exists for hypokinesia and neurological soft signs, while catatonia, abnormal involuntary movements and parkinsonian signs still remain understudied with neuroimaging methods. Soft signs have been associated with altered brain structure and function in cortical premotor and motor areas as well as cerebellum and thalamus. Hypokinesia is suggested to result from insufficient interaction of thalamocortical loops within the motor system. Future studies are needed to address the neural correlates of motor abnormalities in prodromal states, changes ...Continue Reading

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Citations

Apr 4, 2016·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Katharina StegmayerSebastian Walther
Jun 4, 2016·CNS Spectrums·Sebastian Walther, Werner Strik
Jul 14, 2016·NeuroImage. Clinical·Petra V ViherSebastian Walther
Jul 8, 2016·Schizophrenia Bulletin·Cristina MartinelliSukhwinder S Shergill
Oct 13, 2016·Schizophrenia Bulletin·Sebastian WaltherKatharina Stegmayer
Apr 22, 2017·Human Brain Mapping·Dusan HirjakKlaus H Maier-Hein
Nov 1, 2017·Current Psychiatry Reports·Sebastian Walther, Vijay A Mittal
Oct 17, 2018·Psychological Medicine·S WaltherS A Shankman
Aug 24, 2019·Brain Structure & Function·Jonas A HospM Reisert
Mar 3, 2020·Psychological Medicine·Manuel J CuestaVictor Peralta
Jun 17, 2020·Expert Review of Neurotherapeutics·Stephanie LefebvreSebastian Walther
Jun 21, 2019·Schizophrenia Bulletin·Eva MennigenCarrie E Bearden
Jun 24, 2017·European Psychiatry : the Journal of the Association of European Psychiatrists·R AbboudV A Diwadkar
Dec 20, 2017·Neuropsychobiology·Werner StrikThomas Dierks
Apr 17, 2020·Schizophrenia Research·Petra V ViherSebastian Walther
Apr 28, 2021·Biological Trace Element Research·Mehran Shayganfard
Aug 7, 2021·Schizophrenia Bulletin·Petra Verena ViherSebastian Walther
Mar 26, 2019·Neuropsychobiology·Ivanka RistanovicVijay A Mittal

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