PMID: 6408652Apr 1, 1983Paper

Psychoneuroendocrine effects of neurotoxic lesions in the septum and striatum of rats

Pharmacology, Biochemistry, and Behavior
D M Nance

Abstract

The psychoneuroendocrine effects of electrolytic septal lesions were compared with neurotoxic lesions in the lateral septum or striatum of rats induced by 6-hydroxydopamine (6-OHDA) or kainic acid (KA). Lesion effects were examined in terms of changes in body weight (BWt) regulation, ovarian compensatory hypertrophy (OCH) and female sexual behavior. Septal injections of 6-OHDA selectively reduced septal levels of dopamine (DA) by 60% whereas striatal injections reduced striatal levels of DA by 77% and septal levels by 30%. Significant effects of these various lesions were relative to controls (1) KA lesions in the septum increased and 6-OHDA lesions in the striatum decreased BWt; (2) 6-OHDA lesions in the striatum reduced ovarian weight and KA lesions in the septum increased OCH; (3) electrolytic septal lesions increased and KA septal lesions decreased female sexual behavior; (4) the effects of estrogen on food intake and BWt were attenuated in KA septal lesioned rats. Since this experiment failed to show an inhibitory role for DA on lordotic behavior, in a second experiment brain levels of DA were depleted by 6-OHDA injections in the ventral tegmental area or substantia nigra. Levels of female sexual behavior for these animals...Continue Reading

Citations

Jan 1, 1986·Pharmacology, Biochemistry, and Behavior·T R King, D M Nance
Dec 17, 2009·Hormones and Behavior·Karla S FrohmaderLique M Coolen
Nov 25, 2014·The European Journal of Neuroscience·Arojit MitraElena Timofeeva
Jun 21, 2006·Hippocampus·Yusaku TakamuraTaketoshi Ono
Mar 5, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jessica Martin, Elena Timofeeva
Dec 18, 2020·Frontiers in Behavioral Neuroscience·Vic Shao-Chih Chiang, Jin Ho Park

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