Psychoneuroendocrinological and immunological parameters in cancer patients: involvement of stress and depression

Psychoneuroendocrinology
F LechinF Gomez

Abstract

Plasma noradrenaline (NA), adrenaline (A), dopamine (DA), platelet serotonin (pS), free serotonin (fS), cortisol (CRT), growth hormone (GH), peripheral blood lymphocytes (lymph), lymphocyte subpopulations (LSS) and CD4/CD8 ratio were serially assessed in 50 non-medicated, advanced cancer patients (spontaneous evolution) and in age- and sex-paired controls. Clonidine tests and psychiatric evaluations were also serially performed. Patients showing long symptomless periods had all normal values except for raised pS, whereas those who remained free of symptoms for only a short time had raised NA, A and CRT, plus lowered pS values. Further increases in NA, A and CRT, plus additional increases in DA and fS, occurred during exacerbation periods, during which times reductions in lymph, LSS and NK also were observed. Patients in terminal stages showed maximal decreases of all neurotransmitters and immunological parameters; only DA and fS remained raised. Psychiatric interviews performed simultaneously with the clonidine tests revealed a low incidence of moderate depression during symptomless periods and no depression during exacerbation periods. Several significant positive and negative correlations between neurotransmitters and immunol...Continue Reading

References

Jan 1, 1989·International Journal of Cancer. Supplement = Journal International Du Cancer. Supplement·S FerriniL Moretta
Jan 1, 1986·Annals of the New York Academy of Sciences·W C ClarkM N Janal
Jan 1, 1985·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·J K Kiecolt-GlaserG Bonnell
May 1, 1985·Alcoholism, Clinical and Experimental Research·R R WatsonC Eskelson
Jul 1, 1986·The Journal of Clinical Endocrinology and Metabolism·C D MalchoffR M Carey
Jan 1, 1981·Annual Review of Microbiology·G F Solomon, A A Amkraut
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Dec 1, 1981·The American Journal of Psychiatry·K L DavisP A Berger
Feb 1, 1983·Journal of Affective Disorders·F LechinL Arocha
Jan 1, 1980·Neuroscience and Biobehavioral Reviews·S AmirZ Amit
Sep 1, 1984·Psychosomatic Medicine·S E LockeR M Williams
Jan 1, 1982·Psychotherapy and Psychosomatics·D L Udelman
Oct 2, 1981·Science·R B Herberman, J R Ortaldo
Jun 1, 1956·The American Journal of Medicine·S WOLF

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Citations

Nov 1, 1990·Digestive Diseases and Sciences·F LechinS Villa
Dec 13, 2006·Digestive Diseases and Sciences·Fuad Lechin, Bertha van der Dijs
Aug 1, 1996·Progress in Neuro-psychopharmacology & Biological Psychiatry·F LechinM Benaim
Mar 26, 2004·Psychoneuroendocrinology·Fuad LechinAlex E Lechin
Sep 1, 1996·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·F LechinA E Lechin
Jul 11, 2013·American Journal of Therapeutics·Fuad LechinBetty Pardey-Maldonado
Jun 18, 1998·Annals of the New York Academy of Sciences·D SpiegelD P Stites
Sep 24, 2013·International Urology and Nephrology·Sazzad HassanGeorge Kulik
Jan 15, 2000·Journal of Neuroimmunology·S Basu, P S Dasgupta
Mar 1, 2008·Cellular Immunology·Denise L BellingerDianne Lorton
Sep 8, 2009·Journal of Neuroimmunology·Rodrigo PachecoSebastián Bernales
Oct 7, 2003·Palliative Medicine·Staffan Lundström, Carl Johan Fürst
Apr 10, 2007·Digestive Diseases and Sciences·James T DuniganJennifer L Steel
Jul 1, 1993·Archives Internationales De Physiologie, De Biochimie Et De Biophysique·P A Deschaux
Dec 9, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Fuad LechinDenisa Zlacka

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