Psychopathological traits and 5-HT2A receptor promoter polymorphism (-1438 G/A) in patients suffering from Anorexia Nervosa and Bulimia Nervosa

Neuroscience Letters
V RiccaS Sorbi

Abstract

Various studies have evaluated the possible role of the -1438G/A polymorphism within the 5-HT2A receptor gene in the susceptibility to Eating Disorders (EDs). One hundred and forty-eight ED patients (EDp) and 89 control subjects were interviewed by means of the Eating Disorder Examination (EDE) and analyzed for distribution of the -1438G/A polymorphism. Patients with the AA genotype suffering from Anorexia Nervosa and Bulimia Nervosa showed higher Weight and Shape Concern (P = 0.003 and P = 0.010, respectively) scores and greater overall severity of the ED psychopathology (EDE total score) (P = 0.012). The obtained preliminary data suggest the use of dimensional psychopathological measures in ED genetic studies.

References

Jan 7, 2000·Neuroscience Letters·B NacmiasS Sorbi
Apr 25, 2000·Annual Review of Medicine·W H KayeM Strober
Jan 19, 2002·American Journal of Human Genetics·D E GriceW H Berrettini
Mar 26, 2002·Human Molecular Genetics·Bernie DevlinWalter H Kaye
Apr 13, 2002·Neuroscience Letters·Valdo RiccaSandro Sorbi
Oct 19, 2002·Biological Psychology·David M EvansN G Martin
May 29, 2003·Current Drug Targets. CNS and Neurological Disorders·Federica Tozzi, Cynthia M Bulik
Nov 19, 2003·European Journal of Pharmacology·Philip GorwoodChristine Foulon

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Citations

Jun 13, 2006·Psychopharmacology·Michio NomuraYasuyuki Nomura
Dec 2, 2004·Critical Care Nursing Clinics of North America·Martina M Cartwright
Dec 1, 2013·Revista colombiana de psiquiatría·Alma D Genis-MendozaHumberto Nicolini
May 5, 2010·Psychiatric Genetics·Elena CelliniBenedetta Nacmias
Jul 7, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Kenneth R BruceSimon N Young
Jun 24, 2017·Asia-Pacific Psychiatry : Official Journal of the Pacific Rim College of Psychiatrists·Qing KangZeping Xiao
Jul 5, 2019·Expert Review of Neurotherapeutics·Alfredo B Cuellar-BarbozaSusan L McElroy
Aug 13, 2020·Eating and Weight Disorders : EWD·Sirine Abou Al HassanLama Mattar
Jun 15, 2019·Brain and Behavior·Alma Delia Genis-MendozaHumberto Nicolini

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