PMID: 2511737Oct 1, 1989Paper

Psychopathology during long-term lithium treatment of patients with major affective disorders. A prospective study

Acta Psychiatrica Scandinavica
A Nilsson, R Axelsson

Abstract

Thirty-seven patients with major affective disorders according to DSM-III and on continuous lithium treatment were followed during a 7-year period. Outcome was assessed by use of the Comprehensive Psychopathological Rating Scale and by the need for additional psychotropic medication and for hospital and outpatient care. Anamnestic variables and patient's attitudes to their lithium medication were also included in the analysis of outcome, as were laboratory data, including lithium parameters. An increase in psychopathology was demonstrated in a significant number of patients and was attributed mainly to an increase in the depressive symptoms, with a significant increase in the rated scores for fatiguability, pessimistic thoughts, reduced sleep, and inner tension. Suicidal thoughts were common, but no suicide attempts were made. A significant number of patients complained of failing memory, but no significant progression was demonstrated during the 7-year study period. The increase in the depressive symptoms was closely correlated with the number of hospital admissions for depressive recurrence and with the number of days in hospital. The following factors showed a significant relationship with the increase in depressive symptoms...Continue Reading

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Citations

Jan 1, 1991·European Archives of Psychiatry and Clinical Neuroscience·R Axelsson, A Nilsson
Jan 1, 1992·European Archives of Psychiatry and Clinical Neuroscience·R Axelsson, M Lagerkvist-Briggs
Oct 1, 1990·Journal of Affective Disorders·A KørnerJ K Larsen
Sep 15, 2005·Journal of Clinical Psychopharmacology·Wolfram Emanuel SeverusHans-Juergen Moeller
Apr 7, 2007·International Clinical Psychopharmacology·Nikolaus KleindienstWaldemar Greil
Dec 1, 1990·Acta Psychiatrica Scandinavica·A Nilsson, R Axelsson
Jul 1, 1991·Acta Psychiatrica Scandinavica·A Nilsson, R Axelsson
Feb 1, 1992·Acta Psychiatrica Scandinavica·J Modestin, F Schwarzenbach
May 20, 2008·Journal of Affective Disorders·Leandro F Malloy-DinizHumberto Corrêa
Jan 1, 1995·European Psychiatry : the Journal of the Association of European Psychiatrists·G DarcourtB Bensmaïl

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