PMID: 6104996Jun 1, 1980Paper

Psychopharmacologic spectrum of melanostatin

Biulleten' eksperimental'noĭ biologii i meditsiny
A V Val'dmanSh V Svirskis

Abstract

Experiments on cats revealed an emotiotropic action of melanostatin on the original spectrum of emotional reactivity, similar to the effects of L-DOPA and amantadin. The drug does not possess an antidepressant action proper but activates the aggressive-defensive behaviour in experimental reserpine depression and reduces the provocation-induced aggressive behaviour in experimental haloperidol depression. In reserpinized mice, it antagonizes reserpine hypothermia, increases muscle tone and eliminates ptosis. It decreases haloperidol-induced catalepsia. Melanostatin increases the brain level of dopamine and its metabolite, homovanilic acid.

References

Nov 1, 1975·Pharmacology, Biochemistry, and Behavior·R M KostrzewaM A Spirtes
Jan 1, 1979·European Journal of Pharmacology·S Chiu, R K Mishra
Jun 18, 1971·Biochemical and Biophysical Research Communications·R M NairA V Schally
Apr 1, 1971·The International Journal of Neuroscience·M E Celis, S Taleisnik
Jul 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·N P PlotnikoffA V Schally

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