Psychopharmacological effects of oxycodone in healthy volunteers: roles of alcohol-drinking status and sex.

Drug and Alcohol Dependence
James Zacny, Melinda Drum

Abstract

Studies have shown that alcohol-drinking status modulates psychopharmacological effects of several drugs. We sought to determine if drinking status modulates the effects of a prescription opioid, oxycodone, in healthy volunteers. We included sex of the volunteer in the statistical analyses since this is a factor that is known to alter several pharmacodynamic effects of opioids in nonhumans and humans. Fifteen light drinkers (eight males) and 14 moderate drinkers (eight males) participated in a crossover, randomized, double-blind study in which they received 0, 10, and 20mg of oxycodone (p.o.). Dependent measures were subjective, psychomotor/cognitive, reinforcing, and physiological effects. Self-reported alcohol-drinking status did not modulate the effects of oxycodone. However, there were a number of Sex x Dose interactions with females reporting more and larger unpleasant effects than males (e.g., visual analog scale ratings of "nauseated" greater in females than in males). Studies have established that moderate drinkers report a greater degree of abuse liability-related effects than do light drinkers with several different drugs, including diazepam, amphetamine, and nitrous oxide, but we were unable to establish this with th...Continue Reading

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Citations

Jul 30, 2010·Drug and Alcohol Dependence·James P Zacny, Jenny M Jun
Nov 17, 2011·Pharmacology, Biochemistry, and Behavior·James P ZacnyDennis W Coalson
Apr 25, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Manuela Graziani, Robert Nisticò
Jan 28, 2017·Psychopharmacology·Maria MavrikakiElena Chartoff
Nov 28, 2017·Clinical Psychology Review·R Kathryn McHughShelly F Greenfield

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