Oct 8, 1999

Psychopharmacology in autism

Psychosomatic Medicine
L Y Tsai

Abstract

Autism is a neurobiological disorder. The core clinical features of autism include impairment in social interaction, impairments in verbal and nonverbal communication, and restricted, repetitive, and stereotyped patterns of behavior, interests, and activities. Autism often has coexisting neuropsychiatric disorders, including seizure disorders, attention deficit hyperactivity disorder, affective disorders, anxiety disorder, obsessive-compulsive disorder, and Tourette disorder. No etiology-based treatment modality has been developed to cure individuals with autism. However, comprehensive intervention, including parental counseling, behavior modification, special education in a highly structured environment, sensory integration training, speech therapy, social skill training, and medication, has demonstrated significant treatment effects in many individuals with autism. Findings from preliminary studies of major neurotransmitters and other neurochemical agents strongly suggest that neurochemical factors play a major role in autism. The findings also provide the rationale for psychopharmacotherapy in individuals with autism. This article reviews studies of neurochemical systems and related psychopharmacological research in autism a...Continue Reading

  • References85
  • Citations31

References

  • References85
  • Citations31

Citations

Mentioned in this Paper

Diagnostic Radiology Modality
Neurosteroids
Epilepsy
Brain
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Obsessive-Compulsive Disorder
Autistic Disorder
Single Seizure
Etiology
Sensory Integration

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