Psychopharmacology of central serotonergic systems

Pharmacopsychiatry
H G Baumgarten, Z Grozdanovic

Abstract

Serotonin neurons in the rostral and caudal brainstem raphe nuclear groups give rise to collateralized ascending and descending projections which provide modulatory input into most networks throughout the entire neuraxis. The rostral raphe system is interconnected with target forebrain areas through reciprocal limbic-midbrain loops, which suggests that serotonin has a role in the regulation of complex intelligent adaptive behavior. Serotonergic pathways sensitize brainstem and spinal cord central rhythmic pattern generators which organize repetitive autonomic and motor activities, e.g. oral-buccal and nutritive behaviors, facilitate tonically active motor neurons innervating antigravity muscles, and disfacilitate somatosensory information processing. Serotonin effects are mediated by multiple receptor subtypes with distinct pre- and postsynaptic localization and regional distribution pattern. They belong to the G protein superfamily, coupling to adenylate cyclase (5-HT1,4,5,6,7) or phospholipase C (5-HT2), and to the ligand-gated ion channel superfamily (5-HT3). Drugs acting at these receptors are known to modulate various aspects of cooperative social behavior and responding latency, i.e. impulsivity, in a variety of experimen...Continue Reading

Citations

Aug 7, 1998·Biological Psychiatry·I Lucki
Oct 23, 1997·Critical Care Clinics·K C Mills
May 4, 2000·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J A MarcussonL G Gunnarsson
Jun 26, 2009·Social Cognitive and Affective Neuroscience·Arwen B LongMichael L Platt
Sep 3, 2013·Biological & Pharmaceutical Bulletin·Yukihiro OhnoKentaro Tokudome
Oct 4, 2012·Journal of Psychiatry & Neuroscience : JPN·Ayyappan AnithaNorio Mori
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·W E LyonsL Tessarollo
Dec 28, 2012·Journal of Neural Transmission·Bin Tang, Nachum Dafny
Sep 21, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Keri Martinowich, Bai Lu
May 1, 2001·Alcoholism, Clinical and Experimental Research·A HeinzD Goldman
Apr 6, 2004·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Viola Andresen, Stephan Hollerbach
Nov 11, 2008·The Psychiatric Clinics of North America·Victoria L Codispoti
Oct 13, 2015·Progress in Neurobiology·Yukihiro OhnoMasashi Sasa
Aug 1, 2006·Journal of Psychiatric Research·Boris SchifferTillmann H C Krueger
Jul 11, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Saki ShimizuYukihiro Ohno
Sep 14, 2016·Human Brain Mapping·Bernadet L KlaassensJoop M A van Gerven
May 26, 2017·Expert Opinion on Investigational Drugs·Silvia CerriFabio Blandini
Jul 25, 2006·The International Journal of Neuroscience·Reuven Sandyk
Feb 6, 2018·Journal of Neural Transmission·Annalisa PinnaNicola Simola
Dec 24, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Robert D RogersCameron S Carter
Jan 13, 2015·Journal of Genetics·Madhumita RoyBiplob Koch
Aug 29, 2021·Pharmaceuticals·E Maruthi Prasad, Shih-Ya Hung

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