PMID: 9175160Apr 1, 1997Paper

Psychopharmacology of dopamine: the contribution of comparative studies in inbred strains of mice

Progress in Neurobiology
S Puglisi-Allegra, S Cabib

Abstract

Comparative studies of behavioral responses to centrally acting drugs in inbred strains of mice which show differences in brain neurotransmitter activity represent a major strategy in the investigation of the neurochemical bases underlying behavioural expression. Moreover, these studies represent a preliminary stage in behavioral genetic research since they allow quantitative scales to be established and suggest correlations to be tested in recombinant inbred strains. The present review evaluates results obtained in mice of the C57BL/6 (C57) and DBA/2 (DBA) inbred strains which have been used for studies of the behavioral pharmacology of dopamine (DA) and investigated for the functional and anatomical characteristics of their brain DA systems. Differences between C57 and DBA strain involve susceptibility and sensitivity as well as qualitative differences in the type or direction of the behavioral effects of DA agonists. Moreover, data on strain-dependent differences for DA metabolism, release and receptor densities and distribution provide important indications about the relationship between behavioral and central effects of DA agonists and, more generally, about the involvement of brain DA in behavior. Comparative studies in C...Continue Reading

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Citations

Jul 31, 2009·Behavior Genetics·Susanna Pietropaolo, Wim E Crusio
Mar 14, 2002·Physiology & Behavior·Cristina OrsiniSimona Cabib
Oct 20, 2010·Proceedings of the National Academy of Sciences of the United States of America·John A MorrisAllan R Jones
Apr 29, 2006·Genes, Brain, and Behavior·R MaiyaR D Mayfield
Apr 23, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Arthur LebloisDavid J Perkel
Oct 8, 1999·Psychosomatic Medicine·G Torres, J M Horowitz
Jun 24, 2008·Journal of Applied Animal Welfare Science : JAAWS·Carol HallNatalie Waran
Mar 2, 2011·Neuropharmacology·Kelly SkeltonBekh Bradley-Davino
Jul 22, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Philipp SingerBenjamin K Yee
Feb 9, 2010·Pharmacology, Biochemistry, and Behavior·Scott E BowenSusan Irtenkauf
Sep 26, 2009·Psychiatric Annals·Ananda B AmstadterKarestan C Koenen
Feb 6, 2007·Journal of Chemical Neuroanatomy·Loredana D'EsteTindaro G Renda
Apr 1, 2006·Alcoholism, Clinical and Experimental Research·Jennifer Lynn ShortAndrew John Lawrence
Mar 27, 2010·Synapse·Neil M RichtandRobert K McNamara
Nov 28, 2006·Neuroscience and Biobehavioral Reviews·B F P BroekmanF Boer

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