Psychopharmacotherapy in pregnancy and breast feeding

Fortschritte der Neurologie-Psychiatrie
E DavidsO Benkert

Abstract

The primary purpose of this article is to review critically the literature on the use of psychotropic medications in pregnancy and during breast feeding in order to suggest strategies for the clinical management of these periods. Use of psychotropic medications during pregnancy may cause three complications: 1. teratogenicity, 2. perinatal syndromes (neonatal toxicity), and 3. postnatal behavioural sequelae (behavioural toxicity). The literature features few well-controlled studies concerning these points, so that the available information allows only few conclusions. Exposure to certain psychotropic drugs in utero may increase the risk for some specific congenital anomalies; there is mostly no strong evidence for behavioural toxicity in children exposed to psychotropic medications. Use of psychotropic drugs during pregnancy and breast feeding may be appropriate in many clinical situations and should include thoughtful weighing of risk of pre- and postnatal exposure versus risk of relapse following drug discontinuation. The authors try to present disorder-based guidelines for psychotropic drug use during pregnancy and breast feeding and for psychiatrically ill women who wish to conceive.

Citations

Dec 21, 2006·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·Anke Rohde
Jan 13, 2010·Der Nervenarzt·G GründerP Bartenstein
Oct 12, 2010·Der Nervenarzt·C LahmannA Dinkel
Sep 8, 2012·Der Nervenarzt·G GründerM Paulzen
Dec 21, 2013·Der Nervenarzt·T PollmächerD Riemann
Nov 19, 2014·Der Nervenarzt·G Gründer, T Bartsch

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