Psychopharmacotherapy of posttraumatic stress disorder.

Croatian Medical Journal
Dragica Kozaric-Kovacic

Abstract

Posttraumatic stress disorder (PTSD) is a psychiatric disorder that develops after a psychological trauma usually caused by a situation perceived as deeply threatening to a person's life or integrity. Complex neurobiological changes triggered by such a traumatic and stressful experience may explain a wide range of PTSD symptoms and provide the rationale for psychopharmacological treatment. Selective serotonin-reuptake inhibitors make the first-line treatment of PTSD. Clinical experience has shown that they are more effective than noradrenalin-reuptake inhibitors or tricyclic antidepressants. Antipsychotic drugs, especially atypical ones, have been shown effective in PTSD patients with psychotic characteristics or refractoriness to other treatments. Mood stabilizers seem to reduce mostly autonomous overreactions to stress, whereas the evidence for effectiveness of monoamine oxidase inhibitors is largely inconclusive. Other groups of medications, such as serotonin agonists and antagonists, new antidepressants, dual inhibitors of serotonin- and noradrenalin-reuptake, anticonvulsants, and opiate antagonists are also sometimes used in PTSD treatment. However, as shown in the present review, most clinical studies performed to date to...Continue Reading

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Citations

Jul 31, 2013·Neuropharmacology·Sairam KrishnamurthyKeerikkattil P Joy
May 15, 2009·Journal of Clinical Psychopharmacology·Hua JinDilip V Jeste
Jun 1, 2012·International Journal of Peptides·Brian HallKeith K Parker
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Mar 1, 2019·Molecular Psychiatry·Gal Richter-LevinMathias V Schmidt
Apr 11, 2018·Metabolic Brain Disease·Zhi-Kun QiuJi-Sheng Chen
Jun 15, 2021·Expert Opinion on Pharmacotherapy·Ansab Akhtar, Sangeeta Pilkhwal Sah

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