Psychophysical and vasomotor evidence for interdependency of TRPA1 and TRPV1-evoked nociceptive responses in human skin: an experimental study

Pain
Thomas Arendt NielsenHjalte H Andersen

Abstract

The TRPA1 and TRPV1 receptors are important pharmaceutical targets for antipruritic and analgesic therapy. Obtaining further knowledge on their roles and interrelationship in humans is therefore crucial. Preclinical results are contradictory concerning coexpression and functional interdependency of TRPV1 and TRPA1, but no human evidence exists. This human experimental study investigated whether functional responses from the subpopulation of TRPA1 nociceptors could be evoked after defunctionalization of TRPV1 nociceptors by cutaneous application of high-concentration capsaicin. Two quadratic areas on each forearm were randomized to pretreatment with an 8% topical capsaicin patch or vehicle for 24 hours. Subsequently, areas were provoked by transdermal 1% topical capsaicin (TRPV1 agonist) or 10% topical allyl isothiocyanate ("AITC," a TRPA1 agonist), delivered by 12 mm Finn chambers. Evoked pain intensities were recorded during pretreatments and chemical provocations. Quantitative sensory tests were performed before and after provocations to assess changes of heat pain sensitivity. Imaging of vasomotor responses was used to assess neurogenic inflammation after the chemical provocations. In the capsaicin-pretreated areas, both the...Continue Reading

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Citations

Feb 26, 2019·The British Journal of Dermatology·D RiccioL Arendt-Nielsen
Sep 29, 2020·Frontiers in Cellular Neuroscience·Kseniia KorolevaGuzel Sitdikova
Jan 10, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mayur J PatilArmen N Akopian
May 18, 2019·Inflammopharmacology·Diéssica Padilha DalenogareGabriela Trevisan
Feb 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·James N CampbellBenedict Duncan X Lascelles
Oct 16, 2021·Lab Animal·Suzan MeijsWinnie Jensen

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